我的疟疾防治之路——李国桥访谈  

My road to malaria control: an interview with Li Guoqiao

作　　者：张晓红(采访)[1] 肖雄 李国桥[3] 

机构地区：[1]广州中医药大学图书馆,510006 [2]不详 [3]广州中医药大学

出　　处：《中华医史杂志》2019年第1期38-48,共11页Chinese Journal of Medical History

基　　金：广州中医药大学高水平建设项目。

摘　　要：为解决抗药性恶性疟疾的防治问题,中国于1967年启动"523"任务,广州中医学院参与其中,李国桥担任工作小组组长,先后被派往海南、云南等恶性疟疾暴发流行地区进行抗疟治疗。在防治疟疾的过程中,李国桥不惜牺牲个人身体健康以试验临床效果,促使研究方向由从最初的针灸治疟转变为抗疟药物临床观察、重型疟疾与脑型疟救治。在云南开展抗疟工作期间,李国桥应用口服青蒿素,最早初步验证了青蒿素对恶性疟和脑型疟的临床疗效,此后他与团队重回海南,与其他工作组开展青蒿素研究的协作大会战,进一步证实了青蒿素抗疟的优良效果。李国桥致力于青蒿素的国际推广,带领团队先后前往柬埔寨和越南救治当地脑型疟患者,提出"灭源灭疟法",先后应用于柬埔寨与科摩罗,取得了极大成效。为实现全民服药防治疟疾,李国桥至今仍在研究更便宜、更方便服用的新一代青蒿素复方。In order to prevent and treat drug-resistant falciparum malaria,China began the task named“534”in 1967.Guangzhou University of Chinese Medicine participated in this task,Li Guoqiao was one of the leaders.He and his team were sent to Hainan and Yunnan to prevent and cure falciparum malaria.Li risked his health to test clinical effect during the task.This made the therapy shift from acupuncture to antimalarial drugs,and researchers focus on the treatment of severe malaria and cerebral malaria.When he was working at Yunnan,he used oral artemisinin to treat patients with falciparum malaria and Cerebral malarial successfully.It is the first time proven that artemisinin could be used to cure malarial.After that Li and his team came back to Hainan,cooperated with other teams by using artemisinin to treat malarial.Li Guoqiao devoted himself to the international team work for the cure of artemisinin.From 1970s to 1990s,he once went to Cambodia and Vietnam to cure many local Cerebral malaria patients by using artemisinin.Also,he is the first person who invented“FEMSE”(Fast Elimination of Malaria by Source Eradication).He used this kind of method to help patients at Comoros,and achieved great objective.In order to benefit all people,Li Guoqiao is still exploring a new generation of artemisinin compounds that are more economical,and more convenient for patients.

关 键 词：李国桥 青蒿素 疟疾 口述史 

分 类 号：R384.1[医药卫生—医学寄生虫学]