北疆地区哈萨克族人群A_2亚型、MNS、P、Kell血型表型分布调查  

Distribution of A_2, MNS, P, and Kell serological phenotype in the Kazak nationality living in northern Xinjiang of China

作　　者：邱芬 古力巴哈提 文军[2] 田雪梅 阿斯木古丽 潘卉 QIU Fen;Gulibahati;WEN Jun;TIAN Xuemei;Asmuguli;PAN hui(Department of transfusion,Kuitun Hospital of Xinjiang's Ili Kazak Autonomous Prefecture,Kuitun 833200,China;Department of Transfusion,Xinjiang Uygur Autonomous Region People' s Hospital;Department of transfusion, Friendship Hospital of Xinjiang' s Ili Kazak Autonomous Prefecture.)

机构地区：[1]新疆伊犁哈萨克自治州奎屯医院输血科,新疆奎屯833200 [2]新疆维吾尔自治区人民医院输血科 [3]新疆伊犁哈萨克自治州友谊医院输血科

出　　处：《中国输血杂志》2019年第1期60-63,共4页Chinese Journal of Blood Transfusion

基　　金：新疆维吾尔自治区自然科学基金(201442137-24)

摘　　要：目的了解新疆北疆地区哈萨克族人群A_2亚型、MNS、P、Kell血型表型的多态性,建立哈萨克族人群稀有血型抗原的资料。方法随机选择新疆北疆地区哈萨克族人群的无关个体6 862人,采用血型血清学盐水试管法进行A、B、A_1、M、N、P_1、K抗原检测,采用卡式微柱凝胶抗球蛋白法,进行S、s、k抗原检测。结果 1)受检人群A_2亚型在A型中的检出率为7.08%,AB型中的检出率为21.79%;2)MNS、P、Kell血型系统等位基因频率,依次为:M=0.566 8,N=0.433 2,S=0.186 0,s=0.814 0,P1=0.284 8,P2=0.715 2,K1=0.009 6,K2=0.990 4,用χ~2检验,比较基因型频率分布的观察值与期望值,符合Hardy-Weinberg遗传法则(P>0.05);3)检出MNS血型系统罕见S-s-表现型14例,频率为1.16%。4)Kell血型系统中K抗原频率为1.92%,检出罕见KK纯合子1例,频率为0.034%。结论新疆北疆地区哈萨克族人群A_2亚型、MNS、P、Kell血型基因频率分布,具有本民族特征。MNS血型存在独特的基因类型,Kell血型K抗原阳性率明显高于汉族。Objective To understand the polymorphisms of the A2 subtype,MNS,P,and Kell phenotypes in the Kazak population of northern Xinjiang and to establish data on rare blood group antigens in the Kazakh population.Methods 6 862 unrelated individuals in the Kazak population of northern Xinjiang were randomly selected. The antigen of A,B,A1 ,M,N,P1 and K was detected by blood type serological saline test tube method. The antigen of S,s and K was detected by the card type microcolumn gel antiglobulin method. Results 1) A2 subtype,the detection rate in type A was 7. 08%,and the detection rate in AB type was 21. 79%. 2) The allele frequencies of MNS,P and Kell blood type were successively: M= 0. 566 8,N= 0. 433 2,S = 0. 186 0,S = 0. 814 0,P1 = 0. 284 8, P2 = 0. 715 2,K1 = 0. 009 6,K2 = 0. 990 4. using the χ^2test,The Observation value and expectation of genotype frequency distribution were compared. Conform to the Hardy-Weinberg genetic rule ( P>0. 05). 3) Detecting the rare gene phenotype of MNS blood group system in Kazak population,namely S-s-14 cases,with a frequency of 1. 16%. 4) The frequency of K antigen in the Kell blood group system was 1. 92%,and 1 cases of rare KK homozygote were detected,with a frequency of 0. 034%. Conclusion The gene frequency distribution of A2 subtype,MNS,P and Kell blood type of the Kazakh population in North Xinjiang in Xinjiang region have the characteristics of own ethnic. The MNSs blood type has a unique genetype. and Kell blood type K antigen positive rate is significantly higher than that of the Han nationality.

关 键 词：红细胞血型 A2亚型 MNS P Kell 基因频率 哈萨克族 

分 类 号：R457.11[医药卫生—治疗学]