干燥综合征与肠道菌群相关性研究进展  

Research progress of relation between Sjogren's syndrome and gut microbiota

作　　者：刘雨诗 江晓丹[1] 郝然 李学民[1] Liu Yushi;Jiang Xiaodan;Hao Ran;Li Xuemin(Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院眼科,100191

出　　处：《中华眼科医学杂志（电子版）》2019年第1期56-60,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：首都卫生发展科研专项项目(首发2018-2-4093).

摘　　要：肠道菌群在人体免疫系统中发挥着重要作用,肠道菌群及其代谢物的异常与一系列免疫性疾病密切相关。干燥综合征作为自身免疫性疾病的一种,其发病可能与多种因素相关。近年来的一系列研究提示肠道菌群通过调节肠道局部与全身免疫反应,会对干燥综合征的发生与发展产生重要影响。本文中笔者对干燥综合征患者的肠道菌群改变、肠道菌群对干燥综合征的影响及二者可能的免疫学联系进行阐述。The gut microbiota plays a critical role in the human immune system,and abnormalities of the intestinal flora and its metabolites are closely related to a series of systemic autoimmune diseases.Sj?gren’s syndrome is one of the most common autoimmune disease whose onset may be relevant to a variety of factors.Over the recent years,emerging studies are suggesting that gut microbiota may be correlated with the occurrence or development of Sj?gren’s syndrome,through profoundly affecting the local and systemic immune responses.This review describes the gut microbiota changes in patients with Sj?gren’s syndrome,as well as itseffects on the disease and the possible immunological pathogenesis.

关 键 词：肠道菌群 干燥综合征 自身免疫 

分 类 号：R593.2[医药卫生—内科学]