血清诱骗受体3γ-干扰素和抗环瓜氨酸肽抗体在风湿性关节炎患者中的表达及意义  

Expression and Significance of Serum Decoy Receptor 3,Interferon-gamma and Anti-cyclic Citrullinated Peptide Antibodies in Patients with Rheumatic Arthritis

作　　者：邓秋萍[1] 莫巧璇[1] 简少珍[1] 张间霞[1] DENG Qiuping;MO Qiaoxuan;JIAN Shaozhen(Foshan Hospital of Traditional Chinese Medicine, Guangdong Foshan 528000, China)

机构地区：[1]广东省佛山市中医院医学检验中心,广东佛山528000

出　　处：《河北医学》2019年第4期699-702,共4页Hebei Medicine

基　　金：广东省佛山市卫生和计生局科研课题;(编号:A20190096)

摘　　要：目的:探讨血清诱骗受体3、γ-干扰素、抗环瓜氨酸肽抗体在风湿性关节炎患者中的表达及意义。方法:选择2017年2月至2017年12月我院接诊的70例风湿性关节炎患者作为观察组,并选择我院同期接受健康体检的65例健康受试者作为对照组,采集所有受试者入组后第2天清晨空腹静脉血,检测血清诱骗受体3、γ-干扰素、抗环瓜氨酸肽抗体的表达,分析血清诱骗受体3、γ-干扰素、抗环瓜氨酸肽抗体在风湿性关节炎患者中的变化及意义。结果:观察组血清诱骗受体3、γ-干扰素、抗环瓜氨酸肽抗体分别为(4631.05±3180.24) pg/m L、(1341.23±482.94) pg/m L、(86.51±6.38) U/m L,对照组分别为(481.53±150.07) pg/m L、(248.79±62.63) pg/m L、(45.41±8.35) U/m L,差异具有统计学意义(P <0.05);通过Pearson相关性分析显示,血清诱骗受体3、γ-干扰素和抗环瓜氨酸肽抗体水平呈正相关(r=0.658、0.744,P <0.05)。结论:风湿性关节炎患者中血清诱骗受体3、γ-干扰素、抗环瓜氨酸肽抗体均明显升高,且血清诱骗受体3、γ-干扰素和抗环瓜氨酸肽抗体水平均呈正相关,可辅助诊断风湿性关节炎。Objective: To investigate the expression and significance of serum decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. Methods: Seventy patients with rheumatoid arthritis admitted to our hospital from February 2017 to December 2017 were selected as observation group, and 65 healthy subjects who received health examination in our hospital during the same period were selected as control group. Fasting venous blood was collected from all subjects on the morning of the 2nd day after admission. The expression of serum decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibody was detected. The changes and significance of serum decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis were analyzed. Results: The serum levels of decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibodies in the observation group were (4631.05 (+3180.24) pg/mL,(1341.23 (+482.94) pg/mL and (86.51 (+6.38) U/mL, respectively, while those in the control group were (481.53 (+150.07) pg/mL,(248.79 (+62.63) pg/mL and (45.41 (+8.35) U/mL, respectively, with statistical differences (P<0.05);Pearson correlation analysis showed that the serum levels of decoy receptor 3, interferon and anti-cyclic Cit Deception receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibody levels were positively correlated (r = 0.658, 0.744, P<0.05). Conclusion: The serum levels of decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis were significantly increased, and the serum levels of decoy receptor 3, interferon-gamma and anti-cyclic citrullinated peptide antibodies were positively correlated, which could assist in the diagnosis of rheumatoid arthritis.

关 键 词：血清诱骗受体3 Γ-干扰素 抗环瓜氨酸肽抗体 风湿性关节炎 

分 类 号：R593.22[医药卫生—内科学]