参芪扶正注射液联合血府逐瘀汤对PRS患者Pcv-aCO_2及血乳酸的影响  

Effect of Qi-Benefiting Blood-Activating Method on the Pcv-aCO_2 and LAC in Patients with Post-resuscitation Syndrome

作　　者：苏懿[1] 陈银结[1] 郭倩倩[2] 于娜[1] 张云海[1] 马明远[1] SU Yi;CHEN Yin-jie;GUO Qian-qian;YU Na;ZHANG Yun-hai;MA Ming-yuan(Foshan Hospital of Chinese Medicine,Foshan Guangdong 528000, China;Guangdong Provincial Hospital of TCM, Guangzhou Guangdong 510000, China)

机构地区：[1]佛山市中医院,广东佛山528000 [2]广东省中医院,广东广州510000

出　　处：《中医药导报》2019年第6期86-88,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2015年佛山市创新型城市建设科技项目(2015AG1001)

摘　　要：目的:观察参芪扶正注射液联合血府逐瘀汤对复苏后综合征(post-resuscitation syndrome,PRS)气虚血瘀证患者的临床疗效,及其对动静脉二氧化碳分压差(Pcv-aCO_2)和血乳酸(LAC)的影响。方法:将62例PRS气虚血瘀证患者随机分为对照组和治疗组,两组患者均按照治疗指南行常规治疗,治疗组在此基础上加用参芪扶正注射液和血府逐瘀汤治疗,观察两组患者治疗前后气虚血瘀证候积分、急性生理与慢性健康状况评分(APACHE)Ⅱ、序贯器官衰竭估计评分(SOFA)、Pcv-aCO_2和LAC水平、生存率,以及Pcv-aCO_2和LAC的相关性。结果:治疗组中医证候总有效率为60.0%,高于对照组的46.2%,差异有统计学意义(P<0.05)。两组患者治疗后APACHEⅡ评分、SOFA评分均较治疗前下降,且治疗组SOF评分低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后Pcv-aCO_2、LAC均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。患者治疗前后的Pcv-aCO_2和LAC均呈正相关(r前=0.091,r后=0.101,P<0.05)。结论:参芪扶正注射液联合血府逐淤汤能提高PRS气虚血瘀证患者的临床疗效,改善气虚血瘀证候积分、Pcv-aCO_2和LAC水平。Objective: To observe the curative effect of qi-benefiting blood -activating method (QBBAM) on the post-resuscitation syndrome (PRS) patients with qi deficiency and blood stasis syndrome (QDBSS), especially to observe its effect on central venous-arterial carbon dioxide difference (Pcv-aCO2) and blood lactic acid (LAC). Methods: 62 PRS patients with QDBSS were randomly assigned to control group and experimental group, 31 in each group. All patients were followed the AHA Guideline of the 2010 International Cardiopulmonary Resuscita-tion. Patients in the experimental group were additionally injected with Shenqi Fuzheng injection (参英扶正注射液)and fed with Xuefu Zhuyu Tang (血府逐瘀汤).Survival rate and indices including levels of Pcv-aCO2, LAC, APACHEII scores and SOFA scores were measured and compared before and after treatment. Results: After 3- days treatment,, the APACHEII scores of both groups were lower than before (P<0.05), but had no statistically significant difference between each other. Moreover,the QDBSS scores, SOFA scores, Pcv-aC02 and LAC of the experimental group after treatment were lower than control group (P<0.05), while the 3-days and 7-days survival rate were the same in both groups (P<0.05). In addition, the Pcv-aC02 level of 62 patients before and after treatment were positively correlated with LAC (rbefore=0.091, rafter=0.101, P<0.05). Conclusions: The integration of traditional Chinese medicine with QBBAM as well as western medicine treatment, compared with a pure western medicine treatment, could reduce the QDBSS scores, the levels of Pcv -aCO2 and LAC, exert certain clinical curative effect.

关 键 词：复苏后综合征 参芪扶正注射液 血府逐瘀汤 动静脉二氧化碳分压差 血乳酸 

分 类 号：R278[医药卫生—中医学]