流体化学在对羟基苯乙酮合成中的应用  

The Application of Flow Chemistry in the Synthesis of p-Hydroxy-acetophenone

作　　者：金灿[1] 俞传明[1] JIN Can;YU Chuan-ming(Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China)

机构地区：[1]浙江工业大学药学院绿色制药协同创新中心,浙江杭州310014

出　　处：《合成化学》2019年第4期289-292,共4页Chinese Journal of Synthetic Chemistry

基　　金：浙江工业大学青年英才项目(GY16031160003)

摘　　要：以苯酚为原料,采用流体化学技术,依次经醋酐酯化和酸催化Fries重排反应合成了对羟基苯乙酮,其结构经~1H NMR,^(13)C NMR和MS(ESI)确证。使用流体化学反应技术合成对羟基苯乙酮具有操作简便、反应选择性好和产品收率高等优点。p -Hydroxyacetophenone was synthesized using phenol as the raw material through esterification and Fries rearrangement under acid condition. Both steps were carried out under continuous flow conditions. The structure was confirmed by ^1H NMR,^13C NMR and MS(ESI). Synthesizing p -hydroxyacetophenone via flow chemistry has several advantages such as simple operation, good selectivity, high yield, etc.

关 键 词：流体化学 过程强化 对羟基苯乙酮 合成 综合实验 

分 类 号：O626[理学—有机化学] O629.3[理学—化学]