火针联合光疗治疗白癜风随机对照试验的Meta分析  

A meta-analysis on randomized controlled trial of fire needle combined with phototherapy for vitiligo

作　　者：王禹毅[1] 李敏[1] 卢芳[1] 宁春竹 温馨[1] 熊琼 陶春蓉[1] 贾瑞玲 刁庆春[1] 娄方璐[1] WANG Yuyi;LI Min;LU Fang;NING Chunzhu;WEN Xin;XIONG Qiong;TAO Chunrong;JIA Ruiling;DIAO Qingchun;LOU Fanglu(Department of Dermatology,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400014,China)

机构地区：[1]重庆市中医院皮肤科,400014

出　　处：《重庆医学》2019年第7期1172-1175,1179,共5页Chongqing medicine

基　　金：重庆市科研院所绩效激励引导专项(cstc2017jxj1130036);重庆市社会民生科技创新专项(csct2016shms-zd);成都中医药大学医院专项(YYZX20180034)

摘　　要：目的系统评价火针联合光疗治疗白癜风的疗效及安全性。方法系统、全面检索国内外相关数据库,检索日期截至2018年3月。纳入火针联合光疗对比单用光疗治疗白癜风的随机对照试验,采用国际公认的评价标准对纳入研究的质量进行评价,进而对疗效进行系统综合分析。结果共纳入7项随机对照试验,涉及531例白癜风患者。纳入的研究普遍方法学质量较差。对于复色10%,火针联合308准分子激光中短期(6、12周)优于单用308准分子激光[RR:3.44(0.87,13.56)、3.11(1.34,7.22)],长期(15周)无明显差异[RR:2.10(0.70,6.29)];火针联合NB-UVB无论是中短期还是长期都优于单用NB-UVB。对于复色50%,火针联合308准分子激光无论是中短期还是长期都优于单用308准分子激光;火针联合NB-UVB短期(8周)与单用NB-UVB无明显差异[RR:2.73(0.65,11.51)],中长期(12、16周)优于单用NB-UVB[RR:4.13(1.97,8.68)、6.55(1.91,22.49)]。未有严重的不良事件。结论与单用光疗相比,火针联合光疗在治疗白癜风疗效方面存在优势,但需要进一步大样本严格设计的临床试验给予证实。Objective To systematically review the effectiveness and safety of fire needle combined with phototherapy on vitiligo.Methods The international and domestic databases were retrieved till Mar 2018.The randomized controlled trials(RCTs)about the comparison between fire needle combined with phototherapy and phototherapy alone in treatment of vitiligo were identified and included.The methodological quality of included RCTs was reviewed according to internationally recognized criterions,and then the effect was analyzed systematically and comprehensively.Results There were totally 7 RCTs involving 531 patients with vitiligo.The methodological quality of included RCTs was generally poor.Regarding>10%repigmentation,fire needle plus 308 nm excimer laser had better effect than 308 nm excimer laser alone in short and medium term(6,12 weeks),there were statistically significant differences[RR:3.44(0.87,13.56)],3.11(1.34,7.22)];while in long term(15 weeks)no obvious difference was found[RR:2.10(0.70,6.29)].Fire needle plus NB-UVB had better effect in any term.Regarding>50%repigmentation,fire needle plus 308 nm excimer laser had better effect in any term.Fire needle plus NB-UVB had better effect in medium and long term(12,16 weeks),there were statistically significant differences[RR:4.13(1.97,8.68),6.55(1.91,22.49)];while in short term(8 weeks)no obvious difference was found[RR:2.73(0.65,11.51)].No serious adverse events was reported.Conclusion Compared with phototherapy alone,fire needle plus phototherapy have advantages in treatment of vitiligo,but more rigorous designed and large-sample clinical studies are needed for further confirmation.

关 键 词：白癜风 火针疗法 光疗法 随机对照试验 META分析 

分 类 号：R246.7[医药卫生—针灸推拿学]