铜催化C—C/C—N键活化合成2,4,6-三芳基吡啶的研究  

SYNTHESIS OF 2,4,6-TRIARYLPYRIDINE DERIVATIVES VIA COPPER CATALYZED C—C/C—N BOND CLEAVAGE

作　　者：谭怀山 Tan Huaishan(Sinopec Great Wall Energy and Chemical Co., Ltd.. Guizhou 520102,Guiyang, China)

机构地区：[1]中国石化长城能源化工有限公司,贵州贵阳520102

出　　处：《精细石油化工》2019年第2期41-44,共4页Speciality Petrochemicals

摘　　要：研究了在无溶剂条件下,由铜盐催化的苄胺与查尔酮的C—N/C—C键活化串联反应,合成了一系列2,4,6-三芳基吡啶衍生物。重点考察了催化剂、反应温度和反应溶剂等因素对目标产物产率的影响,并通过核磁氢谱和碳谱对串联产物进行了结构鉴定。实验结果表明:在无溶剂情况下,三氟甲磺酸铜(Cu(OTf)_2)催化合成2,4,6-三芳基吡啶衍生物的产率高(60%～88%),该方法具有反应条件温和,原料易得和底物适用范围广等特点。An efficient copper-catalyzed C-N/C-C bond cleavage of aromatic methylamines andα,β-unsaturated ketones was developed to construct 2,4,6-triarylpyridine derivatives under neat conditions.The effects of catalyst,reaction temperature and solvent were studied.The product structures were characterized by ^1H NMR and ^13C NMR.This simple fragment assembly strategy uses mild conditions and affords a broad range of 2,4,6-triarylpyridine derivatives in up to 60%-88% yield from simple and readily available starting materials.This method has the advantages of operational simplicity,simple and readily available starting materials and wide substrate scope.

关 键 词：吡啶类化合物 铜催化 C—C/C—N 键活化 无溶剂反应 

分 类 号：O626.32[理学—有机化学]