SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization  

作　　者：Hang Fu Nan Liu Qiang Dong Chunxiao Ma Jing Yang Jun Xiong Zhuqiang Zhang Xiangbing Qi Chang Huang Bing Zhu 

机构地区：[1]College of Biological Sciences, China Agricultural University, 100094 Beijing, China [2]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, W0101 Beijing, China [3]National Institute of Biological Sciences, 102206 Beijing, China [4]College of Life Sciences, University of Chinese Academy of Sciences, 100049 Beijing, China

出　　处：《Cell Research》2019年第3期254-257,共4页细胞研究（英文版）

基　　金：the Ministry of Science and Technology of China (2017YFA0504200 and 2015CB856200);the National Natural Science Foundation of China (31701101, 31730047, 31521002, and 31425013);the Chinese Academy of Sciences (QVZDYSSW- SMC031, XDB08010103, and XDPB1001);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017133 and 2018127).

摘　　要：Dear Editor, Centromeres are critical for the faithful inheritanee of genetic information during cell division and maintenance of centromere identity is vital for genome integrity. The identity of centromeres is epigenetically determined by centromere-specific histone H3 varia nt, which is termed CENP-A in mammals. Un like canon ical histones that are incorporated into chromatin during S phase in a replication-dependent manner, CENP-A is incorporated into centromeric chromatin during G1 phase in mammals.

关 键 词：SENP6-mediated M18BP1 deSUMOylation CENP-A 

分 类 号：Q[生物学]