Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa  

作　　者：MA Cheng-Yao LU Jia-Hui LI Xiang LIU Xiao CHEN Jian-Wei 

机构地区：[1]Pharmaceutical Institute, Nanjing University of Chinese Medicine [2]Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing

出　　处：《Chinese Journal of Natural Medicines》2019年第4期291-297,共7页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81573577,81274057 and 81403082)

摘　　要：Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.

关 键 词：ANNONA SQUAMOSA Annonaceous ACETOGENINS Cytotoxicity MULTIDRUG resistance 

分 类 号：R284[医药卫生—中药学]