New octadecanoid derivatives from the seeds of Ipomoea nil  

作　　者：SONG Xiu-Qing ZHANG Jun-Sheng YU Shu-Juan YU Jin-Hai ZHANG Hua 

机构地区：[1]School of Chemistry and Chemical Engineering, University of Jinan [2]School of Biological Science and Technology, University of Jinan

出　　处：《Chinese Journal of Natural Medicines》2019年第4期303-307,共5页中国天然药物（英文版）

基　　金：supported by the Natural Science Foundation of Shandong Province(No.JQ201721);the Young Taishan Scholars Program(No.tsqn20161037);the Director Foundation of XTIPC,CAS(No.2015RC015);Shandong Talents Team Cultivation Plan of University Preponderant Discipline(No.10027)。

摘　　要：Four new octadecanoid derivatives(1–4) including a pair of enantiomers(1/2), along with 12 known analogues(5–16), were isolated from the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better a-glucosidase inhibitory activity than the positive control acarbose(IC_(50) 167.7 ± 1.55 μmol×L^(-1)), with IC_(50) of 92.73 ± 3.12 and 11.39 ± 2.18 μmol×L^(-1), respectively.Four new octadecanoid derivatives(1–4) including a pair of enantiomers(1/2), along with 12 known analogues(5–16), were isolated from the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better a-glucosidase inhibitory activity than the positive control acarbose(IC_(50) 167.7 ± 1.55 μmol×L^(-1)), with IC_(50) of 92.73 ± 3.12 and 11.39 ± 2.18 μmol×L^(-1), respectively.

关 键 词：Ipomoea nil Octadecanoid Fatty acid Natural enantiomer α-Glucosidase inhibition 

分 类 号：R284[医药卫生—中药学]