儿童肺炎支原体感染肺外损害166例分析  

Analysis of 166 cases of extrapulmonary damage caused by mycoplasma pneumoniae in children

作　　者：叶玲飞 王宁玲[2] YE Lingfei;WANG Ningling(Department of Paediatrics,Anqing Hospital Affiliated to Auhui Medical University,Anqing,Anhui 246002,China;Department of Paediatrics,The Second Hospital ofAnhui Medical University,Hefei,Anhui 230000,China)

机构地区：[1]安徽医科大学附属安庆医院儿科,安徽安庆246002 [2]安徽医科大学第二附属医院儿科,安徽合肥230000

出　　处：《安徽医药》2019年第5期929-932,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的了解儿童肺炎支原体(mycoplasma pneumoniae,MP)感染流行现状,分析并总结儿童肺炎支原体感染合并肺外损害的发病特点、临床表现、治疗方案及预后。方法以被动凝集法检测安徽医科大学附属安庆医院2015年5月至2016年4月因下呼吸道感染住院儿童的血清MP抗体,对合并肺外损害的166例病儿的起病特点、临床表现、实验室检查等进行回顾性分析。结果 (1)1 329例病儿共检出支原体抗体阳性病儿369人,阳性率为27.8%。夏秋季节检出率更高,差异有统计学意义(χ2=55.540,P<0.05);(2)369例MP感梁病儿中出现肺外损害166例,阳性率为45.0%(166/369)。其中,年龄<3岁组、3～6岁组、>6岁组中肺外损害发生率分别为19.3%(32/166)、39.2%(65/166)、41.5%(69/166)。差异有统计学意义(χ2=63.121,P<0.05);(3)肺炎支原体可引起全身各脏器、系统肺外损害,以心血管系统最为常见(23.2%)。结论 (1)肺炎支原体感染可发生在任何年龄儿童,婴幼儿亦不少见。(2)不同季节肺炎支原体感染发生率不同,夏秋季节高发。(3)肺炎支原体感染可引起多系统肺外损害,其中以心血管系统损害更常见。(4)年龄>3岁儿童更易发生肺外损害。Objective This paper aims to know infection prevalence trend of children mycoplasma pneumoniae infection,analyze and summarize pathogenic characters,clinical manifestation,therapeutic schedule and prognosis of children mycoplasma pneumoniae infection with extra-pulmonary organ damages.Methods The serum MP antibody of children patient with lower respiratory tract infection in Anqing Hospital Affiliated to Auhui Medical University from May 2015 to April 2016 were detected with passive hem-agglutination method and disease characters,clinical manifestation,laboratory inspection of 369 children patients with extra-pulmonary organ damages were retrospectively analyzed.Results(1)In 1 329 children patients,369 were mycoplasma antibody positive with positive rate of 27.8%.Detection rate was higher in summer and autumn,and difference had statistical significance(χ^2=55.540,P<0.05)(.2)Extrapulmonary injury occurred in 166 of the 369 children infected with MP,with a positive rate of 45.0%(166/369).Occurrence rate of organ damages out of lung of younger than 3 years old,3-6 years old and older than 6 years old was 19.3%,39.2%and 41.5%,respectively.Difference had statistics significance(χ^2=63.121,P<0.05)(.3)Mycoplasma pneumoniae may cause all viscera and systematic organ damages out of lung and angiocarpy system is most susceptible(23.2%).Conclusions(1)Mycoplasma pneumoniae infection can occur in children of any age.Infants and young children are also common.(2)Mycoplasma pneumoniae infection rate varies in different seasons,which is higher in summer and autumn.(3)Mycoplasma pneumoniae infection may cause extrapulmonary multiple systematic organ damages,and angiocarpy system is most susceptible.(4)Occurrence rate is higher in children above 3-year-old.

关 键 词：肺炎支原体 感染 肺炎 心血管感染 血凝集试验 婴儿 儿童 

分 类 号：R725.6[医药卫生—儿科]