功能性消化不良病儿应用双歧杆菌三联活菌胶囊联合多潘立酮的胃动力学指标分析  

Analysis of gastric kinetics index in children with functional dyspepsia treated with Bifidobacterium triplex capsule and dapanlitazone

作　　者：杨丽萍[1] YANG Liping(Department of Paediatrics,The Third Hospital of Shijiazhuang,Shijiazhuang,Hebei 050000,China)

机构地区：[1]石家庄市第三医院儿科,河北石家庄050000

出　　处：《安徽医药》2019年第5期1016-1020,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨双歧杆菌三联活菌胶囊联合多潘立酮对功能性消化不良(FD)病儿胃动力学的影响。方法选取2015年6月至2016年8月在石家庄市第三医院儿科门诊诊治的108例FD病儿,按照随机数字表法分成对照组与治疗组,每组54例。对照组予多潘立酮片(吗丁啉)口服每次10 mg,3次/天;治疗组在此基础上再予双歧杆菌三联活菌胶囊口服(每粒0.21 g)2粒/次,次/天。检测血清胃肠激素,评估胃动力学相关指标,评价临床症状评分,比较临床效果。结果治疗组治疗前胃动素(MTL)、神经肽Y(NPY)、血管活性肠肽(VIP)分别为[(206.84±27.14)、(1.40±0.20)、(24.09±3.30)]pg/mL,治疗后为[(338.29±46.42)、(2.34±0.31)、(10.87±1.43)]pg/mL;对照组治疗前为[(206.73±26.58)、(1.41±0.18)、(24.17±3.28)]pg/mL,治疗后为[(281.42±40.02)、(1.88±0.24)、(16.22±2.12)]pg/mL。与治疗前比较,两组病儿胃动素(MTL)、神经肽Y(NPY)升高(P<0.01),血管活性肠肽(VIP)降低(P<0.01)。两组对比,治疗组病儿MTL、NPY较高(P<0.01),VIP较低(P<0.01)。胃动力学变化:治疗后治疗组、对照组胃排空时间为[(25.58±3.39)、(30.78±4.33)]min,较治疗前[(52.62±7.50)、(52.49±7.43)]min缩短(P<0.05),胃窦收缩频率治疗后为[(4.74±0.66)、(3.69±0.47)]次/分,较治疗前[(1.80±0.22)、(1.81±0.23)]次/分升高(P<0.05),胃窦收缩幅度治疗后为[(60.43±8.57)、(51.17±7.07)]mm,较治疗前[(37.01±5.20)、(36.94±5.12)]mm变大(P<0.05);两组对比,治疗组病儿胃排空时间较短(P<0.05),胃窦收缩频率较高(P<0.05),胃窦收缩幅度较大(P<0.05)。临床症状积分两组治疗后均降低(P<0.01),与对照组比较,治疗组积分降低较明显(P<0.01),总有效率较高(P<0.05)。结论双歧杆菌三联活菌胶囊联合多潘立酮治疗小儿FD效果显著,可能与其调节胃肠激素、胃动力的作用有关。Objective To investigate the Bifidobacterium triple viable capsule combined with domperidone on functional dyspepsia(FD)in children with gastric dynamics.Methods 108 children with FD from 2015.6 to 2016.8 in the Third Hospital of Shijiazhuang were divided into control group(54 cases)and treatment group(54 cases)by randon number table method.The control group was treated with Domperidone Tablets(Motilium)10mg tid,the treatment group was treated more with Bifidobacterium triple viable capsules 0.42g tid.The serum gastrointestinal hormones were measured and the gastric motility related indexes and the clinical symptom scores,and the clinical effects were compared.Results In the treatment group,the pre-treatment levels of motilin(MTL),neuropeptide Y(NPY)and vasoactive intestinal peptide(VIP)were:[(206.84±27.14),(1.40±0.20),(24.09±3.30)]pg/mL.the post-treatment levels were:[(338.29±46.42),(2.34±0.31),(10.87±1.43)]pg/mL.In the control group,the pre-treatment levels were:[206.73±26.58),(1.41±0.18),(24.17±3.28)]pg/mL,the post-treatment levels were:[(281.42±40.02),(1.88±0.24),(16.22±2.12)]pg/mL.Compared with before treatment,levels of motilin(MTL),neuropeptide Y(NPY)increased(P<0.01),lev-els of vasoactive intestinal peptide(VIP)decreased(P<0.01).Compared with the control group,levels of MTL,NPY in the treatment group were higher(P<0.01),levels of VIP were lower(P<0.01).Gastrodynamic changes:In the treatment group and in the control group,the post-treatment level of gastric emptying time were(25.58±3.39)and(30.78±4.33)min,shorter than the pre-treatment level of[(52.62±7.50),(52.49±7.43)]min(P<0.05).The Post-treatment levels of gastric sinus contraction frequency were(4.74±0.66)and(3.69±0.47)/min,were higher than the pre-treatment level of[(1.80±0.22),(1.81±0.23)]/min(P<0.05).Scores of antral contraction after treatment were(60.43±8.57)and(51.17±7.07)mm,became larger than before treatment[(37.01±5.20),(36.94±5.12)]mm)(P<0.01).Compared with the control group,levels of shorten the gastric emptying time

关 键 词：消化不良 多潘立酮 有益菌种 促胃动素 神经肽Y 血管活性肠肽 胃排空 双歧杆菌三联活菌胶囊 

分 类 号：R725.7[医药卫生—儿科]