1.2 ml声诺维在肝脏占位病变超声造影中的作用探讨  

Value of 1.2 ml SonoVue dose in contrast-enhanced ultrasonography of liver-occupying lesions

作　　者：刘华丽[1] 潘雨蓉 张敏[1] 杨丽[1] 丁斌 岳文胜[2] LIU Huali;PAN Yurong;ZHANG Min;YANG Li;DING Bin;YUE Wensheng(Department of Ultrasound,the People’s Hospital of Leshan,Sichuan 614000,China)

机构地区：[1]四川省乐山市人民医院超声科,614000 [2]川北医学院附属医院超声科

出　　处：《临床超声医学杂志》2019年第4期251-255,共5页Journal of Clinical Ultrasound in Medicine

基　　金：四川省重点科技计划项目(14SZD109)

摘　　要：目的初步探讨1.2 ml声诺维在肝脏占位病变超声造影检查中的应用价值。方法选取51例使用1.2 ml声诺维(1.2 ml组)和83例使用2.4 ml声诺维(2.4 ml组)行肝脏占位病变超声造影的患者,比较两组超声造影动脉相血流灌注的主要增强方式,对比肝脏良恶性占位病变的时间-强度曲线(TIC)形态特征,分析肝脏占位病灶与周围肝实质血流灌注参数,包括始增时间(AT)、达峰时间(TTP)、上升时间(Δt)、本底强度(Ib)、峰值强度(Ip)、增强强度(ΔI)及ΔI/Δt,以及两组肝脏占位病灶血流灌注参数的差异。结果两组声诺维超声造影下恶性和良性占位病变的主要增强方式相同,恶性占位病变的增强方式主要为整体型和周边增强型,TIC波峰较尖锐。1.2 ml组肝脏占位病变与周围肝实质AT、TTP、Δt、Ib、Ip、ΔI/Δt比较差异均有统计学意义(均P<0.05)。与2.4 ml组比较,1.2 ml组周围肝实质和肝占位病变的AT、TTP、Ib差异均有统计学意义(均P<0.05),1.2 ml组肝血管瘤的TIC参数仅AT差异有统计学意义,肝癌(原发性肝细胞癌和转移性肝癌)的TIC参数仅Ib差异有统计学意义(均P<0.05)。结论使用1.2 ml声诺维行超声造影检查可以较好地显示肝脏占位病变,特别是对肝癌和肝血管瘤的显示,具有较好的临床应用价值。Objective To explore the application value of 1.2 ml SonoVue in the diagnosis of liver lesions by contrastenhanced ultrasonography(CEUS). Methods A total of 51 patients(1.2 ml group)and 83 patients(2.4 ml group)were selected for CEUS. The main enhancement modes of arterial perfusion of CEUS between the two groups were compared. Timeintensity curve(TIC)morphological features of benign and malignant lesions in the liver were compared. The blood perfusion parameters of liver-occupying lesions and peripheral hepatic parenchyma,and the differences in blood perfusion parameters(AT、 TTP、Δt、Ib、Ip、ΔI and ΔI/Δt) between the two groups of liver-occupying lesions were analyzed. Results The main enhancements of malignant and benign liver-occupying lesions were the same in two groups. The enhancement of malignant liver-occupying lesions was mainly holistic and peripheral enhancement,and the peak of TIC was sharp. There were significant differences in TIC perfusion parameters AT,TTP,Δt,Ib,Ip,ΔI/Δt between the 1.2 ml group and the surrounding liver parenchyma(all P<0.05). Compared with the 2.4 ml group,there were significant differences in the TIC perfusion parameters AT,TTP and Ib in the 1.2 ml group and the surrounding liver parenchyma(all P<0.05). Compared with the 2.4 ml group,only AT had statistically significant difference in the TIC perfusion parameters of liver hemangioma in the 1.2 ml group(P<0.05),and only Ib had statistically significant difference in the TIC perfusion parameters of liver cancer(HCC and MLC). Conclusion Using 1.2 ml SonoVue for CEUS can better display liver-occupying lesions,especially for liver cancer and hemangioma,which has good clinical application value.

关 键 词：超声检查 造影剂 肝脏占位病变 良恶性 声诺维 时间-强度曲线 

分 类 号：R445.1[医药卫生—影像医学与核医学] R575[医药卫生—诊断学]