腹膜透析小分子溶质清除评估研究进展  

Advances in the evaluation of small molecule solute clearance in peritoneal dialysis

作　　者：肖希 余学清[1] 阳晓[1] XIAO Xi;YU Xueqing;YANG Xiao(Department of Nephrology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院肾内科,广州510080

出　　处：《中国血液净化》2019年第4期217-219,共3页Chinese Journal of Blood Purification

基　　金：国家自然科学基金(81774069;81570614);国家重点研发计划项目(2016YFC0906100)

摘　　要：小分子溶质清除是腹膜透析患者透析充分性评估的重要组成部分,本研究主要从其主要指标—尿素清除指数的定义、测定方法、与患者预后的相关研究及进展以及其可能的影响因素等方面进行阐述。尿素清除指数被认为与患者的体质量指数、性别、能量代谢率、种族等因素相关,其对腹膜透析患者预后的独立影响作用仍存在争议。在此基础上,本研究对尿素清除指数在腹膜透析小分子溶质清除评估中的作用及其局限性进行深入分析。Small molecule solute clearance is an important parameter in the evaluation of dialysis adequacy of peritoneal dialysis(PD).Here we discuss its main evaluation indicator-Kt/Vurea,including its definition,measurement method,research and progress relating to patient's prognosis,and possible influencing factors.The value of Kt/Vurea is also related to patient's body mass index,gender,energy metabolism rate,ethnicity and other factors.It remains controversial that Kt/Vurea would independently affect the prognosis of PD patients.This review analyzes the role and limitation of Kt/Vurea in the assessment of small molecule solute clearance in PD.

关 键 词：腹膜透析 透析充分性 尿素清除指数 

分 类 号：R459.5[医药卫生—治疗学]