米索前列醇联合缩宫素对预防产后出血及不同给药途径的效果临床观察  

Clinical observation on the effect of misoprostol combined with oxytocin and with different routes of administration on preventing postpartum hemorrhage

作　　者：谢久萍 XIE Jiu-ping(Guangxi Nanning Third People's Hospital,Guangxi Nanning 530003,China)

机构地区：[1]广西南宁市第三人民医院,广西南宁530003

出　　处：《实用妇科内分泌电子杂志》2018年第34期122-123,共2页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨分娩后使用米索前列醇联合缩宫素对预防产后出血的效果及舌下含服和直肠给药的效果观察。方法选择我院300例产妇,对照组(100例):胎儿后2分钟内只肌肉注射缩宫素20 u;实验组(200例):胎儿娩出后2分钟内肌肉注射缩宫素20单位联合米索前列醇400 ug,其中按给药途径分实验组1(100例)直肠塞置米索前列醇片400 ug,实验组2(100例):舌下含服400 ug。观察产后2小时内3组阴道出血及子宫收缩强度,及分析2组实验组不同给药途径的效果对比。结果实验组使用缩宫素联合米索前列醇,子宫收缩强度好,产后出血减少,其预防产后出血效果明显于对照组。不同给药途径对预防产后出血无差异,但直肠给药组不良反应少于舌下含服组。Objective To investigate the effect of misoprostol combined with oxytocin on preventing postpartum hemorrhage and observe the adverse reactions of sublingual and rectal administration.Methods 300 cases of puerpera were selected.In the control group (100 cases),intramuscular injection of 20u oxytocin was only performed within 2 minutes after fetal delivery;in the experimental group (200 cases) intramuscular injection of oxytocin 20 units combined with misoprostol 400 ug within 2 minutes after fetal delivery, and according to the administration route they were further divided into experimental group 1 (100 cases) with 400 μg of misoprostol by rectal administration, and experimental group 2 (100 cases) with sublingual misoprostol 400 ug. to observe 3 groups of vaginal bleeding within 2 hours after delivery and adverse reactions of different drug administration routes in 2 groups.Result In the experimental group using oxytocin combined with misoprostol, the uterine contraction strength was good,and postpartum hemorrhage was reduced. The effect of preventing postpartum hemorrhage was more significant than that of the control group.There was no difference in the prevention of postpartum hemorrhage in the different administration routes,but the adverse reactions in the rectal administration group were less than Sublingual group.

关 键 词：产后出血 产后2小时 预防 不同给药途径 

分 类 号：R714.46[医药卫生—妇产科学]