病毒疫苗对预防胆道闭锁的可行性探讨  

Feasibility of viral vaccine in preventing biliary atresia

作　　者：詹江华[1] 余晨 ZHAN Jiang-hua;YU Chen(Department of Pediatric Surgery,Tianjin Children’s Hospital,Tianjin 300134,China;Graduate School of Tianjin Medical University)

机构地区：[1]天津市儿童医院小儿外科,300134 [2]天津医科大学研究生院

出　　处：《天津医药》2019年第4期339-342,共4页Tianjin Medical Journal

摘　　要：胆道闭锁(BA)是引起新生儿梗阻性黄疸的常见原因,也是导致肝脏功能衰竭的严重的肝胆系统疾病。目前关于BA的病因及发病机制的研究还在继续,但种种迹象表明,围生期病毒感染在BA的发生发展中扮演着重要角色,有可能是引起BA的真正原因。本文主要从病毒疫苗接种的角度出发,探讨其对预防BA的可行性,以期为降低BA的发病率提供一个全新的视角。Biliary atresia(BA)is a common cause of obstructive jaundice in the infantile period,and also a severe hepatobiliary disease leading to liver failure.At present,the research on the etiology and pathogenesis of BA is continuing.But various signs show that perinatal viral infection plays an important role in the occurrence and development of BA,which may be the exact cause of BA.Therefore,this paper mainly discussed the feasibility of preventing BA from the view of virus vaccination,in order to provide a new perspective for reducing the incidence of BA.

关 键 词：胆道闭锁 巨细胞病毒 轮状病毒属 疱疹病毒4型 人 呼肠病毒科 疫苗 

分 类 号：R726.574[医药卫生—儿科]