益气除湿活血汤对代谢综合征大鼠胰岛素抵抗的影响河北医科大学第三医院  

Effect of Yiqi Chushi Huoxue Decoction on Insulin Resistance in Metabolic Syndrome Rats

作　　者：常波伦 郭辉[2] 李猛 张黎[1] CHANG Bo-lun;GUO hui;LI Meng;ZHANG Li(Third Hospital of Hebei Medical University,Shijiazhuang 050051)

机构地区：[1]河北医科大学第三医院,石家庄050051 [2]河北医科大学第四医院,石家庄050011 [3]石家庄市急救中心,石家庄050011

出　　处：《河北中医药学报》2019年第2期6-8,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省中医药管理局科研计划资助项目:No.2017183

摘　　要：目的:以益气除湿活血汤干预代谢综合征(MS)大鼠,并观察其对MS大鼠胰岛素抵抗(IR)的影响,探讨相关的作用机制。方法:采用成年、雄性、胖Zucker大鼠(OZRs)和瘦Zucker大鼠(LZRs),根据大鼠年龄匹配分为3组:胖Zucker大鼠组(OZRs组)、瘦Zucker大鼠组(LZRs组)、高脂高糖喂胖的瘦Zucker大鼠组(L-OZRs组),每组各10只。给药后4周检测大鼠空腹血糖(FPG)、空腹血清胰岛素(FINS)、瘦素(Leptin),计算胰岛素敏感性指数(HOMA-IR)。结果:给药后OZRs组大鼠FPG、FINS、Leptin、HOMA-IR均明显下降(P<0.05);L-OZRs组大鼠FPG、FINS、HOMA-IR均明显下降(P<0.05),而Leptin水平无明显变化(P>0.05);LZRs大鼠各项指标均无明显变化(P>0.05)。结论:益气除湿活血汤可通过改善脂类代谢的表达,抑制IR,达到防止MS的作用。Objective: To observe the effect of Yiqi Chushi Huoxue Decoction on insulin resistance (IR) in rats with metabolic syndrome (MS) and explore its mechanism. Methods: Adult, male, obese Zucker rats (OZRs) and lean Zucker rats (LZRs) were divided into three groups according to age matching: OZRs group, LZRs group and L-OZRs group (lean Zucker rats fed with high fat and sugar), with 10 rats in each group. Fasting blood glucose (FPG), fasting serum insulin (FINS) and Leptin were measured 4 weeks after administration, and insulin sensitivity index (HOMA-IR) was calculated. Results: After administration, FPG, FINS, Leptin and HOMA-IR in OZRs group decreased significantly ( P <0.05);FPG, FINS and HOMA-IR in L-OZRs group decreased significantly( P < 0.05), while Leptin level did not change significantly ( P >0.05);the indexes of LZRs rats did not change significantly ( P >0.05).Conclusion: Yiqi Chushi Huoxue Decoction can prevent MS by improving lipid metabolism and inhibiting IR.

关 键 词：代谢综合征 益气除湿活血汤 消渴 湿阻 眩晕 胁痛 胰岛素抵抗 

分 类 号：R285.6[医药卫生—中药学]