超声双重造影在胃癌肝转移新辅助化疗疗效评估中的应用价值  

Application value of double contrast-enhanced ultrasonography in the evaluation of efficacy of neoadjuvant chemotherapy for gastric cancer with liver metastasis

作　　者：吴玮[1] 阳建军[1] 范慧慧[1] 施林枫[1] 莫丹绯 胡明芳[2] WU Wei;YANG Jianjun;FAN Huihui;SHI Linfeng;MO Danfei;HU Mingfang(Department of Ultrasonography, Central Hospital of Huzhou City, Zhejiang Province, Huzhou 310013, China;Department of Radiology, Central Hospital of Huzhou City, Zhejiang Province, Huzhou 310013, China)

机构地区：[1]浙江省湖州市中心医院超声科,浙江湖州310013 [2]浙江省湖州市中心医院放射科,浙江湖州310013

出　　处：《中国医药导报》2019年第10期142-145,共4页China Medical Herald

基　　金：浙江省医药卫生计划项目(2015KYB377)

摘　　要：目的探讨超声双重造影在胃癌肝转移(GCLM)新辅助化疗疗效评估中的应用价值。方法回顾性分析2016年8月～2017年10月在浙江省湖州市中心医院行新辅助化疗的GCLM患者80例,根据其疗效分为有效组(54例)和进展组(26例),分析比较两组患者治疗后微血管密度(MVD)及峰值强度(PI)、开始增强时间(RT)、到达峰值时间(TTP)、增强强度(EI)等双重造影参数,并分析双重造影参数与MVD的相关性。结果治疗后,所有患者PI、EI较治疗前明显降低(P <0.05),RT、TTP较治疗前明显升高(P <0.05)。治疗后,有效组PI、EI明显低于进展组(P <0.05),RT、TTP明显高于进展组(P <0.05)。治疗后,进展组MVD明显高于有效组,差异有统计学意义(P <0.05)。经相关性分析,MVD与PI、EI呈正相关(r_(PI)=0.275,P=0.013;r_(EI)=0.436,P=0.000),与RT、TTP呈负相关(r_(RT)=-0.287,P=0.021;r_(TTP)=-0.320,P=0.047)。结论超声双重造影参数PI、EI可用于评估GCLM新辅助化疗疗效,且灵敏性较高。Objective To investigate the application value of double contrast-enhanced ultrasonography in the efficacy evaluation of neoadjuvant chemotherapy for gastric cancer with liver metastasis (GCLM). Methods A retrospective analysis of the clinical data of 80 cases of with GCLM who received neoadjuvant chemotherapy in Central Hospital of Huzhou City, Zhejiang Province, from August 2016 to October 2017. All the cases were divided into effective group (54 cases) and progressive group (26 cases) according to clinical efficacy. The microvascular density (MVD) and peak intensity (PI), rising time (RT), time to peak (TTP), enhancement intensity (EI) were compared between the two groups after treatment, and the correlation between double contrast parameters and MVD was analyzed. Results After treatment, PI and EI of all the patients were significantly lower than those before treatment (P < 0.05), and RT and TTP were significantly higher than those before treatment (P < 0.05). After treatment, the MVD in progressive groups was significantly higher than that in the effective group, the difference was statistically significant (P < 0.05). Through correlation analysis, MVD was positively correlated with PI and EI (rPI = 0.275, P = 0.013;rEI = 0.436, P = 0.000), and were negatively correlated with RT and TTP MVD (rRT =-0.287, P = 0.021;rTTP =-0.320, P = 0.047). Conclusion Ultrasound double contrast-enhanced parameters of PI and EI can be used to evaluate the efficacy of neoadjuvant chemotherapy for GCLM, which have high sensitivity.

关 键 词：胃癌 肝转移 超声双重造影 新辅助化疗 微血管密度 

分 类 号：R445.1[医药卫生—影像医学与核医学]