神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病的疗效观察  

Observation on efficacy of ganglioside combined with mouse nerve growth factor on the treatment of neonatal hypoxic ischemic encephalopathy

作　　者：黄振读 黄文哲 戴梅丹 HUANG Zhen-du;HUANG Wen-zhe;DAI Mei-dan(Department of Pediatrics,Guangdong Xuwen County People’s Hospital,Zhanjiang 524100,China)

机构地区：[1]广东省徐闻县人民医院儿科,524100

出　　处：《中国现代药物应用》2019年第7期76-78,共3页Chinese Journal of Modern Drug Application

摘　　要：目的观察神经节苷脂联合鼠神经生长因子对新生儿缺血缺氧性脑病(HIE)的治疗效果。方法 140例新生儿缺血缺氧性脑病患儿,随机分为治疗组和对照组,每组70例。两组患儿均采用常规治疗,治疗组患儿在常规治疗基础上采用神经节苷脂联合鼠神经生长因子治疗。观察比较两组患儿的临床疗效。结果治疗组患儿中预后良好65例,预后不良5例;对照组患儿中预后良好36例,预后不良34例;治疗组患儿的预后良好率92.86%显著高于对照组的51.43%,差异具有统计学意义(P<0.05)。结论神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病效果显著。Objective To observe the treatment effect of ganglioside combined with mouse nerve growth factor on the treatment of neonatal hypoxic ischemic encephalopathy(HIE).Methods A total of 140 children with neonatal hypoxic ischemic encephalopathy were randomly divided into treatment group and control group,with 70 cases in each group.Both groups received conventional therapy,and the treatment group was treated with ganglioside combined with mouse nerve growth factor on the basis of conventional therapy.The clinical efficacy in two groups was observed and compared.Results The treatment group had 65 cases with good prognosis and 5 cases with poor prognosis,and the control group had 36 cases with good prognosis and 34 cases with poor prognosis.The treatment group had significantly higher good prognosis rate as 92.86%than 51.43%in the control group,and the difference was statistically significant(P<0.05).Conclusion Ganglioside combined with mouse nerve growth factor shows remarkable effect on the treatment of neonatal hypoxic ischemic encephalopathy.

关 键 词：新生儿缺血缺氧性脑病 单唾液酸四己糖 神经节苷脂钠 鼠神经生长因子 

分 类 号：R722.1[医药卫生—儿科]