铜催化下含氮化合物的Chan-Lam偶联反应的研究进展  

Progress in Copper-Catalyzed Chan-Lam Coupling of N-Compounds

作　　者：段希焱[1] 刘宁[1] 王佳 马军营[1] Duan Xiyan;Liu Ning;Wang Jia;Ma Junying(School of Chemical Engineering & Pharmaceutics,Henan University of Science and Technology,Luoyang 471023)

机构地区：[1]河南科技大学化工与制药学院

出　　处：《有机化学》2019年第3期661-667,共7页Chinese Journal of Organic Chemistry

基　　金：河南省科技攻关(No.182102310106)资助项目~~

摘　　要：构筑碳-氮键在有机合成和药物化学领域有着重要的意义.近年来关于碳氮键合成反应的研究取得了长足的进展.其中铜催化的 Chan-Lam 偶联反应是构筑碳氮键最有效和直接的方式之一.系统综述了近十多年 Chan-Lam 偶联反应直接构筑 C—N 键的催化机理、反应体系、底物范围及结构特点等.Construction of C-N bond is one of the most important areas in synthetic organic chemistry and medical chemis-try. Many synthetic methods for the construction of C-N bond have been reported over the past few years. Copper-catalyzed Chan-Lam reactions represent one of the most powerful and straightforward tools to construct C-N bonds. In this paper, the recent progress in Chan-Lam coupling of N-compounds with (hetero)aryl boronates to construct C-N bond based on the reac-tion mechanism, reaction system, the scope of substrates, etc., is reviewed.

关 键 词：Chan-Lam 偶联反应 铜催化 C-N 键 芳基硼酸 含氮化合物 

分 类 号：O621.251[理学—有机化学]