人乳头瘤病毒致癌蛋白E6的结构与功能研究进展  

Research Progress in the Structure and Function of Oncoprotein E6 of the Human Papillomavirus

作　　者：王致萍 柳欣林 王大宁[2] 夏宁邵[1,2] 李少伟[1,2] WANG Zhiping;LIU Xinlin;WANG Daning;XIA Ningshao;LI Shaowei(National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Life Sciences,Xiamen University,Xiamen 361102,China;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心生命科学学院,厦门361102 [2]厦门大学分子疫苗学与分子诊断学国家重点实验室公共卫生学院,厦门361102

出　　处：《病毒学报》2019年第2期292-299,共8页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:U1705283);题目:基于结构的人乳头瘤病毒型别交叉疫苗的分子设计和免疫机制研究~~

摘　　要：人乳头瘤病毒(Human papillomavirus,HPV)是一类无包膜的小DNA病毒,主要感染人皮肤上皮细胞和黏膜,持续感染HPV会引起良性和恶性肿瘤,如尖锐湿疣和宫颈癌等多种疾病。HPV早期蛋白E6是引起宿主细胞发生恶性转化的关键致癌蛋白,其参与调节宿主细胞内多个关键的生理生化过程,如促使抑癌蛋白p53的降解、激活端粒酶和降解细胞凋亡相关蛋白Bak(Bcl-2 homologous antagonist/killer)等,进而干扰宿主细胞的生长因子依赖性、细胞凋亡、细胞转录、DNA损伤反应、细胞周期和宿主细胞分化等一系列生命活动。因此,分析阐述HPV致癌蛋白E6的结构与功能,有助于阐明HPV诱发宫颈癌等恶性肿瘤的分子机理,为今后设计治疗性HPV疫苗奠定理论基础。本文就HPV致癌蛋白E6的结构及其生物学功能进行综述。The human papillomavirus(HPV)is a small,non - enveloped,double - stranded DNA virus that infects human cutaneous epithelial cells.Persistent infection with the HPV is the primary cause of benign and malignant epithelial tumors,such as cervical cancer,genital warts and other diseases.Oncogenic protein E6 of the HPV plays a critical role in the malignant transformation of the infected cells.E6 proteins can interact with multi-ple cellular factors,leading to induction of p53 degradation,telomerase activation,and degradation of B - cell lymphoma - 2 homologous antagonist / killer.Furthermore,a range of key cellular proteins and signaling pathways,including growth -factor dependence,apoptosis,transcription,DNA - damage responses,cell - cycle progression,and cell differentiation,are modified by E6 protein.Therefore,understanding how oncoprotein E6 of the HPV affects these pathways may help to elucidate the molecular mechanisms of HPV -associated cancer and provide insights for designing HPV vaccine.Here,we review research progress of structure and function of oncoprotein E6 in the HPV.

关 键 词：人乳头瘤病毒(HPV) 致癌蛋白E6 宫颈癌 P53蛋白 

分 类 号：R373.9[医药卫生—病原生物学] R511[医药卫生—基础医学]