乙戊型肝炎病毒重叠感染的研究进展  

Research Progress in Hepatitis B Virus Superinfection With Hepatitis E Virus

作　　者：余小娟 潘莉莉[1] 苏迎盈[1] 吴婷[1] 黄守杰[1] YU Xiaojuan;PAN Lili;SU Yingying;WU Ting;HUANG Shoujie(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学公共卫生学院分子疫苗学和分子诊断学国家重点实验室国家传染病诊断试剂与疫苗工程技术研究中心,厦门361102

出　　处：《病毒学报》2019年第2期318-322,共5页Chinese Journal of Virology

基　　金：新药创制专项(项目号:2018ZX09303005-002);题目:戊型肝炎疫苗的质量控制研究;疫苗标准品研究;福建省科技重大专项(项目号:2015YZ0002);题目:HEV/HPV多价联合疫苗研究与产品开发~~

摘　　要：戊型肝炎(简称"戊肝")是发展中国家发病率最高的急性病毒性肝炎,疾病负担较重,近年来发达国家也出现越来越多散发的本土病例。我国慢性乙型肝炎(简称"慢乙肝")人群基数大,慢乙肝患者重叠感染戊肝病毒之后,可加重患者病情,增加肝硬化、肝衰竭以及死亡的发生风险。本文拟对乙型肝炎病毒重叠感染戊肝病毒的流行病学特征、临床特征及预防措施进行综述。Hepatitis E is the most common type of acute viral hepatitis in developing countries,and the disease burden is heavy.In recent years,more and more local cases have also presented in developed countries.The Chronic hepatitis B population of China is large,and chronic hepatitis B patients are prone to superinfection with hepatitis E virus,which aggravates the patient′s condition,increasing the risk of cirrhosis,liver failure and death.This article aims to summarize the epidemiological characteristics and clinical features of,and preventive measures for hepatitis B virus superinfection with hepatitis E virus.

关 键 词：戊型肝炎(HE) 戊型肝炎病毒(HEV) 慢性乙型肝炎(CHB) 乙型肝炎病毒(HBV) 重叠感染 

分 类 号：R373.9[医药卫生—病原生物学] R511[医药卫生—基础医学]