黛力新治疗女性高血压伴焦虑抑郁症的临床疗效  

Clinical curative effect of Deanxit in the treatment of female patients with hypertension and anxiety and depression and the impact on quality of life

作　　者：王倩[1] 郜琳[2] 刘永政[1] WANG Qian;GAO Lin;LIU Yongzheng(Department of Cardiovascular Diseases , Qinhuangdao First Hospital, Qinhuangdao 066000, Hebei, China;Department of Geriatrics , Qinhuangdao First Hospital, Qinhuangdao 066000, Hebei, China)

机构地区：[1]秦皇岛市第一医院心血管病一科,河北秦皇岛066000 [2]秦皇岛市第一医院老年病二科,河北秦皇岛066000

出　　处：《西部医学》2019年第4期566-570,共5页Medical Journal of West China

基　　金：河北省卫生厅科研项目(1309254)

摘　　要：目的探讨黛力新治疗女性高血压伴焦虑抑郁症患者的临床疗效及对生活质量的影响。方法选取我院心血管内科2014年12月～2017年3月收治的女性高血压伴焦虑抑郁症患者90例为研究对象,随机分为观察组和对照组,每组各45例,对照组予以常规降压药物(氨氯地平、缬沙坦等)治疗,观察组在此基础上口服黛力新,治疗2周后比较两组降压总有效率及负性情绪[汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)]、血清指标[髓过氧化物酶(MPO)、一氧化氮(NO)、5-羟色胺(5-HT)]变化和生活质量[健康状况调查简表(SF-36)]及不良反应发生率。结果观察组降压总有效率明显高于对照组(P<0.05);观察组治疗后HAMA、HAMD评分均较对照组低(P<0.01);观察组治疗后血清MPO水平低于对照组,而NO、5-HT水平较对照组高(P<0.05);观察组治疗1、2周及结束后1个月SF-36评分明显高于对照组(P<0.01);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论黛力新治疗女性高血压伴焦虑抑郁症患者有助于提高降压效果,改善其负性情绪、生活质量,降低MPO活性,提高NO、5-HT水平,安全可靠,可在临床推广应用。Objective To analyze the clinical curative effect of Deanxit in the treatment of female patients with hypertension, anxiety and depression and the impact on quality of life. Methods 90 female patients with hypertension, anxiety and depression admitted to department of cardiology in the hospital from December 2014 to March 2017 were randomly divided into the observation group and the control group, 45 patients in each group. The control group was treated with routine antihypertensive drugs (amlodipine, valsartan, etc.). On the basis, the observation group was treated with Deanxit. The total effective rate of antihypertensive treatment, negative emotions[Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD)], levels of serum indicators[myeloperoxidase (MPO), nitric oxide (NO), 5hydroxytryptamine (5-HT)] and quality of life[short from health survey (SF-36)] and the incidence of adverse reactions were compared between the two groups after 2 weeks of treatment. Results The total effective rate of antihypertensive treatment in the observation group was significantly higher than that in the control group(P<0.05). The HAMA and HAMD scores in the observation group were lower than those in the control group after treatment (P<0.01). The level of serum MPO was lower than that in the control group after treatment, while the levels of NO and 5-HT were higher than those in the control group (P<0.05). The SF-36 scores of the observation group were significantly higher than those of the control group after 1 week and 2 weeks of treatment, and at 1 month after treatment (P<0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Deanxit can improve the antihypertensive effects, relieve negative emotions, improve quality of life, reduce the activity of MPO and increase levels of NO and 5-HT in female patients with hypertension and anxiety and depression.

关 键 词：黛力新 女性高血压 焦虑抑郁症 临床疗效 生活质量 

分 类 号：R544[医药卫生—心血管疾病]