骨重建过程中降钙素基因相关肽与RANK/RANKL/OPG作用机制的研究进展  

Progress of research on the relationship between calcitonin gene-related peptide and RANK/RANKL/OPG system in the bone reconstruction

作　　者：王诗尧 许少策 师政伟 武建超 雷栓虎[1] 汪玉良[1] WANG Shiyao;XU Shaoce;SHI Zhengwei;WU Jianchao;LEI Shuanhu;WANG Yuliang(Department of Orthopedics,Lanzhou University Second Hospital,Lanzhou Gansu,730000,P.R.China;Orthopedics Key Laboratory of Gansu Province,Lanzhou Gansu,730000,P.R.China)

机构地区：[1]兰州大学第二医院骨科,兰州730000 [2]甘肃省骨关节疾病重点实验室,兰州730000

出　　处：《中国修复重建外科杂志》2019年第4期511-515,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：甘肃省科技支撑计划项目(1304FKCA091)

摘　　要：目的总结骨重建过程中降钙素基因相关肽(calcitonin gene-related peptide,CGRP)与核因子κB受体活化因子(receptor activator of nuclear factorκB,RANK)/核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL)/骨保护蛋白(osteoprotegerin,OPG)信号系统作用机制的研究进展,为进一步研究骨相关疾病的预防及治疗提供理论依据。方法广泛查阅国内外近年来骨重建过程中CGRP与RANK/RANKL/OPG信号系统相关文献,并加以分析总结。结果骨重建过程中,CGRP与RANK/RANKL/OPG信号系统发挥着重要调控作用。结论目前对于骨重建过程中CGRP与RANK/RANKL/OPG信号系统的作用机制研究仍不够深入,需进一步研究二者在骨重建过程中的具体作用方式、相互联系,明确作用机制,为临床上骨相关疾病的治疗带来新思路、新方法。Objective To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases.Methods The relevant research results at home and abroad in recent years were analyzed and summarized.Results CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction.Conclusion At present,the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient.Therefore,it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism,which will bring new ideas and methods for the treatment of bone related diseases in clinic.

关 键 词：骨重建 成骨细胞 破骨细胞 降钙素基因相关肽 核因子ΚB受体活化因子 核因子ΚB受体活化因子配体 骨保护蛋白 

分 类 号：R68[医药卫生—骨科学]