环己酮氧化制备ε-己内酯的工艺研究进展  

Research progress in preparation of ε-caprolactone by cyclohexanone oxidation

作　　者：王媛媛 龚华银 刘赛赛 朱明乔[1,2] Wang Yuanyuan;Gong Huayin;Liu Saisai;Zhu Mingqiao(College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027;Research Institute of ZhejiangUniversity in Quzhou,Quzhou 324000;Taizhou Yuanzhong Pharmaceutical Co.,Ltd,Taizhou 318000)

机构地区：[1]浙江大学化学工程与生物工程学院,浙江杭州310027 [2]浙江大学衢州研究院,浙江衢州324000 [3]台州市源众药业有限公司,浙江台州318000

出　　处：《合成纤维工业》2019年第2期54-61,共8页China Synthetic Fiber Industry

基　　金：浙江省自然科学基金(Y4080247);浙江省重大科技计划项目(2010C01035);广西石化资源加工及过程强化技术重点实验室开放课题基金(K002);工业控制技术国家重点实验室开放课题基金(ICT1224);浙江台州源众药业有限公司资助

摘　　要：综述了近年来环己酮氧化制备ε-己内酯的工艺研究进展并评述了各工艺的优缺点。以环己酮为原料氧化制备ε-己内酯的工艺主要有过氧酸氧化、双氧水氧化、氧气/醛类共氧化和生物氧化等4种氧化工艺,其中过氧酸、双氧水为氧源氧化环己酮制备ε-己内酯的技术已被人们成功掌握。过氧酸氧化法是目前工业大规模生产ε-己内酯的主流。但是,基于当今绿色化学的要求和发展现状,双氧水氧化工艺是最经济和具有发展前景的制备ε-己内酯的工艺,需研发高效稳定的催化剂及其工艺中的除水技术。The research progress in the preparation ofε-caprolactone by cyclohexanone oxidation were reviewed in recent years,as were the advantages and disadvantages of the production processes.The preparation ofε-caprolactone by cyclohexanone oxidation includes four types of oxidation processes:peroxy acid oxidation,hydrogen peroxide oxidation,oxygen/aldehyde co-oxidation and biological oxidation.Among them,the technology of preparingε-caprolactone by oxidizing cyclohexanone with peroxy acid and hydrogen peroxide has been successfully mastered.Peroxy acid oxidation is the mainstream of large-scale industrial production ofε-caprolactone.However,based on the requirements and development status of green chemistry,the oxidation process of hydrogen peroxide is the most economical and promising process for the preparation ofε-caprolactone.It is necessary to develop efficient and stable catalysts and water removal technology in the process.

关 键 词：Ε-己内酯 环己酮 氧化工艺 催化氧化 技术进展 

分 类 号：TQ225.24[化学工程—有机化工]