症状性迟发型性腺功能减退病人下尿路症状调查  

Symptomatic late-onset hypogonadism in men with lower urinary tract symptoms

作　　者：梁国庆[1] 李建辉[2] 孙建明[1] 毛剑敏 王峻[2] 沈育忠 李余敏[2] 于晓华[2] 张树成[3] 李铮[4] LIANG Guo-qing;SUN Jian-ming;LI Jian-hui;MAO Jian-min;WANG Jun;SHEN Yu-zhong;LI Yu-min;YU Xiao-hua;ZHANG Shu-cheng;LI Zheng(Department of Andrology,Seventh People's Hospital of Shanghai University of TCM,Shanghai 200137,China;Department of Urology,the First People's Hospital of Jiashan,Jiaxing 314100,China;Department of Cell Biology,National Research Institute of Family Planning,Beijing 100081,China;Department of Andrology,Urologic Medical Center,the First People's Hospital Shanghai,Shanghai Jiaotong University,Shanghai 200080,China)

机构地区：[1]上海中医药大学附属第七人民医院男性病科,上海市200137 [2]嘉善县第一人民医院泌尿外科,浙江省嘉兴市314100 [3]国家人口计生委科学技术研究所,北京市100081 [4]上海交通大学附属第一人民医院泌尿外科医学中心男科与盆底尿失禁外科,上海市200080

出　　处：《实用老年医学》2019年第4期332-335,共4页Practical Geriatrics

基　　金：上海市浦东新区科技发展基金(PKJ2017-Y11);上海市第七人民医院人才培养计划(QMX2016-02);上海市第七人民医院团队培养项目(WMH2017-10)

摘　　要：目的通过分析症状性迟发型性腺功能减退症(SLOH)病人的下尿路症状(LUTS)患病情况,探讨SLOH与LUTS之间的相关性。方法采用多阶段随机整群不等比例的抽样方法,抽取3000例有固定性伴侣的40～80岁社区中老年男性,采用老年男性症状(AMS)量表及国际前列腺症状评分(IPSS)评估SLOH及LUTS的严重程度,采用Logistic回归分析SLOH与LUTS的相关性。结果共获得符合标准的调查对象2623例,其中SLOH的患病率为39. 04%(1024/2623),LUTS患病率为63. 82%(1674/2623)。伴随着年龄的增长,SLOH及LUTS的患病率均显著增加。无LUTS症状的人群中SLOH患病率为16. 86%,轻度LUTS症状人群的SLOH患病率为42. 89%,而中重度LUTS人群SLOH的患病率为82. 37%。随着LUTS症状程度的增高,SLOH的严重程度明显升高。Logistic回归分析显示:增龄、LUTS严重程度是SLOH的独立影响因素(P<0. 01)。结论中老年男性LUTS病人中存在很高的SLOH发生率。年龄越大,LUTS症状愈严重者SLOH的发生风险更高,临床上在治疗LUTS的同时应该考虑SLOH问题,有效改善其生活质量。Objective To investigate the incidence of symptomatic late-onset hypogonadism(SLOH)in men with lower urinary tract symptoms(LUTS),and to analyze the correlation between SLOH and LUTS.Methods A cross-sectional randomized study of 3000 males were investigated using structured questionnaires including International Prostate Symptom Score(IPSS)and aging male symptoms(AMS)in community.Univariate Logistic regression analysis was used to explore the relationship between SLOH and LUTS.Results The final study population consisted of 2623 men.The incidence of SLOH or LUTS was 39.04%and 63.82%,respectively.The incidence of SLOH was 16.86%,42.89%and 82.37%in the normal group,mild SLOH group and moderate-severe SLOH group,respectively(P<0.01).Logistic regression analysis revealed that aging and LUTS were significantly related to SLOH(P<0.01).Conclusions The incidence of SLOH is high in men with LUTS.The patients with an old age or severe LUTS might have a higher risk of SLOH.

关 键 词：迟发型性腺功能减退 下尿路症状 男性 雄激素 

分 类 号：R698[医药卫生—泌尿科学]