超声辅助离子液体冷诱导微萃取法测定肉类中氟甲喹和萘啶酸  

Determination of flumequine and nalidix acidin meatby ultrasound-assisted ionic liquid cold-induced aggregation microextraction

作　　者：郭宗宁[1] 黄雪琳[1] 林殷[2] 戚琦[3] GUO Zong-ning;HUANG Xue-lin;LIN Yin;QI Qi(Integrated technology center of dongguan enter-exit inspection and quarantine bureau,Dongguan 523000,China;Shantou Entry-Exit Inspection and Quarantine Bureau,Shantou 515041,China;Department of Chemistry and Chemistry Engineering,GannanNormalUniversity,Ganzhou 341000,China)

机构地区：[1]东莞出入境检验检疫局综合技术中心,广东东莞523000 [2]汕头出入境检验检疫局,广东汕头523000 [3]赣南师范大学化学化工学院,江西赣州341000

出　　处：《化学研究与应用》2019年第4期773-776,共4页Chemical Research and Application

基　　金：江西省教育厅科学技术研究项目(GJJ14654)资助

摘　　要：建立了一种样品前处理方法即离子液体冷诱导微萃取,通过超声辅助利用高效液相色谱-紫外检测器测定了鸡肉、猪肉中氟甲喹和萘啶酸的残留含量。考察了萃取剂、抗黏剂、pH值及温度等对萃取效率的影响。在优化的萃取条件下,测定氟甲喹和萘啶酸的线性范围分别为10～300μg·L^(-1)和5-300μg·L^(-1),r=0.9995及0.9997,检出限分别为0.7μg·L^(-1)和0.5μg·L^(-1),平均回收率在90.4%～103.2%,相对标准偏差在2.7%～9.3%之间。本方法具有简单、环保、灵敏度高、抗干扰性强等特点。USA-IL-CIAME followed by high performance liquid chromatography were successfully used for trace detection of flumequine and nalidix acid in chicken and pork.Important parameters affecting extractionefficiency,such as extraction solvent type and volume,anti-sticking agent type and volume,pHandtemperature,were discussed.Linearity of the method was observed over the range 10~300μg·L^-1 for flumequine and 5~300μg·L^-1 for nalidix acid with correlation coefficients up to 0.9995.The sensitivity of the proposed method was found to be excellent with detection limit in range 0.5~0.7μg·L^-1.The recoveries ranged from 90.4%to 103.2%with relative standard deviations(RSD)from 2.7%to 9.3%.All this resultsindicated that the developed method would be a simple,green and sensitive method.

关 键 词：离子液体 冷诱导微萃取 氟甲喹 萘啶酸 

分 类 号：O657.7[理学—分析化学]