白细胞介素及C反应蛋白对老年心血管急症的临床诊断价值分析  

Diagnostic value of interleukin and C reactive protein for aged patients with cardiovascular emergencies

作　　者：刘崇韬 郑志虹[1] 翁志远[1] LIU Chong-tao;ZHENG Zhi-hong;WENG Zhi-yuan(First Department of Cardiology, Central Hospital of Jiamusi City, Jiamusi, Heilongjiang, 154002, China)

机构地区：[1]黑龙江省佳木斯市中心医院心内一科,黑龙江佳木斯154002

出　　处：《心血管康复医学杂志》2019年第2期225-228,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究白细胞介素(IL)及C反应蛋白(CRP)对老年心血管急症的临床诊断价值。方法:选择本院2012年1月至2016年11月诊治的,以急性胸闷、胸痛和呼吸困难等为主要表现的心血管急症患者189例(心血管急症组),另外选择同期150例健康体检者作为健康对照组。检测比较两组血清炎症因子水平。结果:与健康对照组比较,心血管急症组血清IL-1、IL-2、IL-6、IL-10、CRP、同型半胱氨酸(Hcy)、N末端B型利钠肽原(NT-proBNP)、丙二醛(MDA)、还原型辅酶II(NADPH)氧化酶亚基p22、p47、p67、gp91、肿瘤坏死因子(TNF)-α、内皮素(ET)-1及其受体、胱抑素C(CysC)和心肌肌钙蛋白T(cTnT)水平均显著升高,超氧化物歧化酶(SOD)和谷胱甘肽过氧化酶(GSHPX)水平显著降低,P均=0.001。结论:老年心血管急症患者的白细胞介素及C反应蛋白水平显著升高,且此过程中有过氧化酶的参与。Objective: To study diagnostic value of interleukin (IL) and C reactive protein (CRP) for aged patients with cardiovascular emergencies. Methods: A total of 189 patients with cardiovascular emergencies, who were mainly presented as acute chest tightness, chest pain and dyspnea and treated in our hospital from Jan 2012 to Nov 2016, were selected as cardiovascular emergency group. Another 150 cases undergoing physical examination simultaneously were selected as healthy control group. Serum levels of inflammatory factors were measured and compared between two groups. Results: Compared with healthy control group, there were significant rise in serum levels of IL-1, IL-2, IL-6, IL-10, CRP, homocysteine (Hcy), N terminal pro brain natriuretic peptide (NT-proBNP), malonyl diadehyde (MDA), reduced form of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase subunit p22, p47, p67 and gp91, tumor necrosis factor (TNF)-α, endothelin (ET)-1 and its receptor, cystatin C (CysC) and cardiac troponin T (cTnT), and significant reductions in levels of superoxide dismutase (SOD) and glutathione peroxidase (GSHPX) in cardiovascular emergency group, P =0.001 all. Conclusion: Serum levels of IL and CRP significantly rise in aged patients with cardiovascular emergencies, and peroxidase is involved in the process.

关 键 词：心血管疾病 急症 白细胞介素类 C反应蛋白质 

分 类 号：R54[医药卫生—心血管疾病]