中药熏蒸联合玻璃酸钠治疗膝骨性关节炎Meta分析  

Meta-analysis of traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis

作　　者：黎勇[1] 郑臣校[1] 李绪松[1] 徐明国 LI Yong;ZHENG Chen-xiao;LI Xu-song;XU Ming-guo(Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan,Guangdong 528400)

机构地区：[1]广东省中山市中医院,广东中山528400

出　　处：《海南医学院学报》2019年第8期587-592,共6页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(81870364)~~

摘　　要：目的:探讨中药熏蒸联合玻璃酸钠治疗膝骨性关节炎Meta分析。方法:数据库来源于电子检索中国期刊全文数据库CNKI、万方、重庆维普数据库、pubmed等,截止时间为2017年4月,以"中药熏蒸""玻璃酸钠""膝骨性关节炎"为关键词或主题检索,最后得到13篇关于中药熏蒸联合玻璃酸钠治疗膝骨性关节炎的RCT文献,确定结局指标为有效率和痊愈率,观察两组患者治疗后Lysholm's评分,将所有结果输入Review Manager 5.2进行分析。结果:本次共得到13篇关于中药熏蒸联合玻璃酸钠治疗膝骨性关节炎的RCT文献,对照组采用玻璃酸钠或抗炎药物治疗,共619例;研究组均采用玻璃酸钠+中药熏蒸治疗,共649例;森林图合并效应量OR=1.82,Z=5.00(P<0.00001),95%CI(1.44,2.30),说明与玻璃酸钠或抗炎药物比较,采用中药熏蒸联合玻璃酸钠治疗膝骨性关节炎,痊愈率有明显优势;森林图合并效应量OR=5.55,Z=7.44(P<0.00001),95%CI(3.54,8.73),说明与玻璃酸钠或抗炎药物比较,采用中药熏蒸联合玻璃酸钠治疗膝骨性关节炎,有效率有明显优势;森林图合并效应量OR=12.11,Z=5.18(P<0.00001),95%CI(7.53,16.68),说明与玻璃酸钠或抗炎药物比较,采用中药熏蒸联合玻璃酸钠治疗膝骨性关节炎,膝关节功能恢复有优势。结论:中药熏蒸联合玻璃酸钠治疗膝骨性关节炎的痊愈率和有效率均有明显优势,且能更好的恢复膝关节功能,由于纳入的文献较少、质量不高,确切疗效仍需纳入更高质量的RCT文献来证实。Objective:To explore the meta-analysis of traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis.Methods:The database was originated from CNKI,Wanfang,Chongqing Weipu database,PubMed and so on.The deadline was April 2017.The database was searched with the keywords of"Chinese herbal fumigation","sodium hyaluronate"and"knee osteoarthritis".Finally,13 articles about the treatment of Chinese herbal fumigation combined with sodium hyaluronate were obtained.RCT literatures of knee osteoarthritis identified the outcome indicators as the effective rate and recovery rate.Lysholm's score was observed after treatment in both groups,and all the results were input into Review Manager 5.2 for analysis.Results:A total of 13 RCT literatures about the treatment of knee osteoarthritis with Chinese herbal fumigation and sodium hyaluronate were obtained.The control group was treated with sodium hyaluronate or anti-inflammatory drugs,totaling 619 cases.The study group was treated with sodium hyaluronate and Chinese herbal fumigation,totaling 649 cases.The combined effect of forest map OR=1.82,Z=5.00(P<0.00001),95%CI(1.44,2.30).Compared with sodium hyaluronate or anti-inflammatory drugs,fumigation with traditional Chinese medicine combined with sodium hyaluronate has obvious advantages in curing knee osteoarthritis.The combined effect of forest chart OR=5.55,Z=7.44(P<0.00001),95%CI(3.54,8.73),indicating that compared with sodium hyaluronate or anti-inflammatory drugs,traditional Chinese medicine is used.Fumigation combined with sodium hyaluronate has obvious advantages in the treatment of knee osteoarthritis;forest map combined effect OR=12.11,Z=5.18(P<0.00001),95%CI(7.53,16.68),indicating that compared with sodium hyaluronate or anti-inflammatory drugs,traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis can restore knee joint function.Advantages.Conclusion:Chinese herbal fumigation combined with sodium hyaluronate ha

关 键 词：中药熏蒸 玻璃酸钠 膝骨性关节炎 META分析 

分 类 号：R684.3[医药卫生—骨科学]