血栓形成及炎症在子痫前期发生和发展中的作用  

The Role of Thrombosis and Inflammation in the Initiation and Development of Preeclampsia

作　　者：罗丹 邵帅 姜经航 刘洋 龙平 江梅 丁涛 LUO Dan;SHAO Shuai;JIANG Jing-hang;LIU Yang;LONG Ping;JIANG Mei;DING Tao(Department of Obstetrics and Gynecology,Jingmen No.2 People's Hospital,Jingmen 448000,Hubei Province,China;Department of Reproductive Medicine,Jingmen No.2 People's Hospital,Jingmen 448000,Hubei Province,China)

机构地区：[1]湖北省荆门市第二人民医院妇产科,448000 [2]湖北省荆门市第二人民医院生殖医学科,448000

出　　处：《国际妇产科学杂志》2019年第2期173-176,共4页Journal of International Obstetrics and Gynecology

基　　金：湖北省自然科学基金(2017CFC808;2018CFC859);荆门市科技计划项目(2018YFZD013)

摘　　要：子痫前期(PE)是妊娠期常见的并发症,也是导致不良妊娠结局的主要原因,严重者可致母儿死亡。但其发病机制尚不清楚,其发生可能与孕妇年龄、慢性高血压、糖尿病、孕前肥胖和多胎妊娠等有关。PE是一个复杂的多系统疾病,主要涉及胎盘滋养层异常入侵、抗血管生成因子异常表达、氧化应激和炎症反应等。研究发现血栓形成相关因子以及炎症相关因子与PE的发生有关,能够促进病情进展,但具体机制不明。理清血栓形成及炎症在PE发病中发挥的作用可以为PE的早期预防和治疗提供相关策略,现就血栓形成及炎症在PE发生、发展中的作用作一综述。Preeclampsia (PE) is a common complication during pregnancy and a major cause of poor pregnancy outcomes, which can even lead to maternal and child death in severe cases. PE involves multiple links, causing multiple organ, system involvement. Preeclampsia is a complex, multisystem disorder relate to abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress and inflammation. Although there are many studies on PE, the pathogenesis of PE is not clear, and its occurrence may be related to the age of pregnant women, chronic hypertension, diabetes, pre-pregnancy obesity and multiple pregnancy. Studies found that the related factors of thrombus formation and related inflammatory factors are related to the pathogenesis of PE, which can promote the pathogenesis of PE, but the specific mechanism is unknown. Clarifying the correlation of thrombosis and inflammation in the pathogenesis of PE can provide relevant strategies for the early prevention and treatment of PE. Therefore, this paper reviews the role of thrombus formation and inflammation in the pathogenesis and development of PE.

关 键 词：先兆子痫 血栓形成 炎症 血管生成诱导剂 补体系统蛋白质类 凝血致活酶 

分 类 号：R714.244[医药卫生—妇产科学]