贝那普利联合血栓通胶囊对老年2型糖尿病合并高血压患者血管内皮功能的影响  

Effect of Benazepril Combined with Xueshuantong Capsule on Vascular Endothelial Function in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Hypertension

作　　者：陈曼丽[1] 范琳[2] 宫蕊[1] 齐莉莉 CHEN Man-li;FAN Lin;GONG Rui;QI Li-li(Department of Geriatrics, Third Hospital of Shijiazhuang City, Shijiazhuang, Hebei Province, 050000 China;Department of Endocrinology, Third Hospital of Shijiazhuang City, Shijiazhuang, Hebei Province, 050000 China;Department of Pathogenic Biology, School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei Province, 050017 China)

机构地区：[1]石家庄市第三医院老年病科,河北石家庄050000 [2]石家庄市第三医院内分泌科,河北石家庄050000 [3]河北医科大学基础医学院病原生物学教研室,河北石家庄050017

出　　处：《糖尿病新世界》2019年第5期109-110,共2页Diabetes New World Magazine

摘　　要：目的探讨贝那普利联合血栓通胶囊对老年2型糖尿病合并高血压患者血管内皮功能的影响。方法选取该院老年病科2016年10月—2018年10月选取老年2型糖尿病合并高血压患者86例作为研究对象,随机均分为对照组和治疗组。对照组给予贝那普利10 mg/d,治疗组在对照组基础上加服血栓通胶囊1粒/次,3次/d。治疗8周后,观察并比较两组患者血清内皮素1(ET-1)和一氧化氮(NO)等方面的变化。结果治疗后,两组患者的SBP与DBP水平均有明显下降,治疗组在下降幅度上高于对照组,差异有统计学意义(P<0.05)。治疗后ET-1水平均有显著降低,治疗组在降低幅度上高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后NO水平均有显著升高,治疗组在升高幅度上高于对照组,差异有统计学意义(P<0.05)。结论贝那普利联合血栓通胶囊治疗老年2型糖尿病合并高血压患者,可以有效地降低患者血压水平,有助于改善患者血管内皮功能,值得在临床上推广使用。Objective To investigate the effect of benazepril combined with Xueshuantong Capsule on vascular endothelial function in elderly patients with type 2 diabetes mellitus complicated with hypertension. Methods 86 elderly patients with type 2 diabetes mellitus complicated with hypertension were selected from October 2016 to October 2018 in our hospital.They were randomly divided into control group and treatment group. The control group was given benazepril 10 mg/d, and the treatment group was given Xueshuantong Capsule 1 capsule/time, 3 times/d on the basis of the control group. After 8 weeks of treatment, changes in serum endothelin-1(ET-1) and nitric oxide(NO) were observed and compared between the two groups. Results After treatment, both SBP and DBP levels were significantly lower in the two groups. The decrease in the treatment group was higher than that in the control group(P<0.05). After treatment, the level of ET-1 was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). The levels of NO in the two groups were significantly increased after treatment. The increase in the treatment group was higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion Benazepril combined with Xueshuantong Capsule can effectively reduce the blood pressure level of patients with type 2 diabetes mellitus and hypertension. It is helpful to improve the vascular endothelial function of patients and it is worthy of clinical application.

关 键 词：贝那普利 血塞通滴丸 2型糖尿病 高血压 血管内皮 

分 类 号：R587.1[医药卫生—内分泌]