石墨烯材料与蛋白质的相互作用  

Interactions between Graphene Materials and Proteins

作　　者：王晓娟 刘真真 陈奇 王小强 黄方[1] Xiaojuan Wang;Zhenzhen Liu;Qi Chen;Xiaoqiang Wang;Fang Huang(College of Chemical Engineering, China University of Petroleum(East China), Qingdao 266580, China)

机构地区：[1]中国石油大学(华东)化学工程学院,青岛266580

出　　处：《化学进展》2019年第2期236-244,共9页Progress in Chemistry

基　　金：山东省自然科学基金面上项目(No.ZR2017MB039);山东省重点研发计划项目(No.2018GGX102025);青岛市民生科技计划项目(No.17-3-3-76-nsh)资助.

摘　　要：石墨烯材料凭借其优异的物理化学性质在生物化学以及生物医学领域备受关注,展现出了广阔的应用前景。值得注意的是,石墨烯材料在应用于载药、医学检测与诊断及生物成像等诸多领域时,会不可避免地与生物体内的各种蛋白质分子产生相互作用,进而改变石墨烯材料自身的理化性质并影响蛋白质的构象及生物学功能。因此研究石墨烯材料与蛋白质分子之间的相互作用,对于理解和评估其生物学效应,开发新型生物化学技术,具有至关重要的意义。本文综述了近年来针对石墨烯材料与蛋白质分子相互作用开展的代表性的科学研究,分类介绍了石墨烯家族中的各种材料与蛋白质相互作用的分子机制与规律,并介绍了基于蛋白质分子与石墨烯材料相互作用开发的新型应用技术,最后对这一领域未来的热点研究方向进行了分析和展望。Relying on the excellent physical and chemical properties, graphene materials have attracted great attention in the biomedical field and shown broad application prospects. It needs to be noted that when graphene materials are used for bio-applications, such as drug delivery, medical sensing and bioimaging, they will interact inevitably with various proteins and result in the changing of their own properties as well as the variation of proteins' conformation and functions. Therefore, a lot of studies have been carried out to investigate the interactions between graphene materials and protein molecules, which is of vital importance for understanding and evaluating the biological effects of graphene materials. In this content, the representative scientific researches on this topic are reviewed. The molecular mechanisms of the interactions between various materials of the graphene family and proteins are summarized, and the newly developed biotechnologies based on the graphene material / protein interactions are introduced. Finally, some personal perspectives of the further research directions in this field are presented.

关 键 词：石墨烯 氧化石墨烯 蛋白质 相互作用 分子机制 

分 类 号：Q816[生物学—生物工程] O641.3[理学—物理化学]