中风病急性期证候要素及神经功能缺损程度与血浆PRA、AngⅡ、ALD水平的相关性研究  

Correlation between syndrome factors and neurological function defect in acute stroke and PRA,AngⅡ and ALD levels

作　　者：王雅惠 江澜[1] 陈沛[1] 吴爽[1] 耿花蕾 闫如玉 陆梦馨 王月 邹忆怀[1] WANG Yahui;JIANG Lan;CHEN Pei(Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China)

机构地区：[1]北京中医药大学东直门医院脑一科

出　　处：《环球中医药》2019年第4期512-516,共5页Global Traditional Chinese Medicine

基　　金：国家“十二五”科技支撑计划(2013BAI13B02)

摘　　要：目的探究中风病急性期患者血浆肾素(plasma renin activity,PRA)、血管紧张素Ⅱ(angiotensin Ⅱ,Ang Ⅱ)、醛固酮(aldosterone,ALD)水平与证候要素及神经功能缺损程度的相关性。方法收集2014年5月至2017年11月东直门医院收治的急性缺血性中风患者124例,对所有患者进行中风病证候要素及卒中相关量表评价,采用放射免疫分析法检测血浆PRA、AngII、ALD水平,分析上述指标与证候要素及神经功能缺损程度的相关性。结果中风病急性期患者血浆ALD水平与内风证、痰湿证均呈显著正相关,差异有统计学意义( r 值分别为0.000、0.048, P <0.05),PRA、 AngII、ALD与神经功能缺损评分均未见明显相关。结论中风病急性期血浆ALD水平越高,内风证和痰湿证表现越明显;血浆PRA、AngII、ALD水平一定程度上可以帮助监测中风病患者病情、判断预后。Objective To investigate the correlation of PRA, AngII and ALD levels with syndrome factors and neurological deficits in patients with acute stroke. Methods A total of 124 patients with acute ischemic stroke admitted to Dongzhimen Hospital from May 2014 to November 2017 were recruited. All patients were evaluated for stroke syndrome and stroke-related scales. PRA, AngII and ALD levels of all the subjects were tested by radioimmunoassay and analyze the correlation of these indicators with syndrome factors and neurological deficits. Results There were significant positive correlations between plasma ALD levels in patients with acute stroke and internal wind pattern and phlegm-dampness pattern, and the differences were statistically significant ( r = 0.000, 0.048;P <0.05). No correlation was found between the neurological deficits scores and PRA, AngII and ALD. Conclusion Acute ischemic stroke patients with higher ALD levels are more likely to have manifestations of internal wind syndrome and phlegm-dampness syndrome. Plasma PRA, Ang II and ALD levels can monitor the condition and judge the prognosis for stroke patients.

关 键 词：中风病急性期 证候要素 神经功能缺损 肾素 血管紧张素Ⅱ 醛固酮 

分 类 号：R255.2[医药卫生—中医内科学]