新生儿缺氧缺血性脑病后遗症发生情况及其影响因素分析  

Analysis of the Occurrence of Sequelae of Neonatal Hypoxic Ischemic Encephalopathy and Its Influencing Factors

作　　者：何谚 姚霞 HE Yan;YAO Xia(Department of Pediatrics, Dushanzi People's Hospital, Karamay, Xinjiang, 833699 China)

机构地区：[1]新疆克拉玛依市独山子人民医院儿科,新疆克拉玛依833699

出　　处：《中外医疗》2019年第7期38-40,共3页China & Foreign Medical Treatment

摘　　要：目的研究与分析新生儿缺氧缺血性脑病后遗症发生情况及其影响因素,以期为临床新生儿缺氧缺血性脑病后遗症的防治提供科学依据。方法方便选取在2015年12月—2018年5月时间内来该院进行治疗的患有新生儿缺氧缺血性脑病的患儿87例,随后采取问卷调查的方式来对患儿的临床资料进行调查,同时采取回顾性分析法将新生儿缺氧缺血性脑病后遗症发生情况进行回顾性分析,且采取多因素Logistic回归分析新生儿缺氧缺血性脑病后遗症疾病的影响因素。结果在这87例患有缺氧缺血性脑病的新生儿中,有12例患儿出现新生儿缺氧缺血性脑病后遗症,发生率为13.8%。经过多因素Logistic回归分析,结果显示患儿出现宫内感染、生长迟缓等因素以及母体患有心脏病、妊娠高血压综合征、贫血以及分娩时休克等因素均会增加缺氧缺血性脑病患儿产生并发症的发生率(OR=45.902,1.258,1.789,3.177,1.038,0.584,1.728,41.814,1.083,3.212,0.138),数据差异有统计学意义(P<0.05),同时患儿合并有颅内出血、5 min Apger评分等异常均会增加缺氧缺血性脑病患儿产生并发症的发生率(OR=1.093,0.787,3.905,5.094,5.872,23.76,1.562,0.328),数据差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性脑病后遗症发生率较高,且后遗症的影响因素较多,在临床需要积极处理相关危险因素,以此来有效地降低后遗症的发生。Objective To study and analyze the occurrence of sequelae of neonatal hypoxic ischemic encephalopathy and its influencing factors, in order to provide a scientific basis for the prevention and treatment of sequelae of hypoxic ischemic encephalopathy in neonates. Methods 87 children with neonatal hypoxic ischemic encephalopathy who were treated in our hospital from December 2015 to May 2018 were convenient enrolled. The questionnaire was used to analyze the clinical data of the children. The investigation was carried out, and retrospective analysis was performed to retrospectively analyze the occurrence of neonatal hypoxic ischemic encephalopathy sequelae. Multivariate logistic regression analysis was used to analyze the influencing factors of neonatal hypoxic ischemic encephalopathy sequelae. Results Of the 87 neonates with hypoxic ischemic encephalopathy, 12 had neonatal hypoxic ischemic encephalopathy sequelae with an incidence of 13.8%. After multivariate logistic regression analysis, the results showed that intrauterine infection, growth retardation and other factors,as well as maternal heart disease, pregnancy-induced hypertension syndrome, anemia and shock during childbirth, all increased hypoxic ischemic encephalopathy incidence of complications occurrance(OR = 45.902, 1.258, 1.789, 3.177, 1.038,0.584, 1.728, 41.814, 1.083, 3.212, 0.138), the data were statistically significant(P<0.05), and the children had abnormalities such as intracranial hemorrhage and 5 min Apger score increased the incidence of complications in children with hypoxic ischemic encephalopathy(OR = 1.093, 0.787, 3.905, 5.094, 5.872, 23.76, 1.562, 0.328). The data were statistically significant(P<0.05). Conclusion The incidence of sequelae of neonatal hypoxic ischemic encephalopathy is high, and there are many influencing factors of sequelae. It is necessary to actively deal with related risk factors in clinical practice, so as to effectively reduce the occurrence of sequelae.

关 键 词：新生儿 缺氧缺血性脑病 后遗症 影响因素 

分 类 号：R4[医药卫生—临床医学]