MHD合并长期高血压患者采用血液灌流法治疗的效果分析  

Effects of hemoperfusion on patients with long-term hypertension and undergoing MHD

作　　者：胡小梅 王戈[1] 章晶晶 Hu Xiaomei;Wang Ge;Zhang Jingjing(Internal medicine, Xishui county traditional Chinese medicine hospital, Huanggang, Hubei, 438200, China)

机构地区：[1]浠水县中医院内科,湖北黄冈438200

出　　处：《当代医学》2019年第13期93-96,共4页Contemporary Medicine

摘　　要：目的探讨维持性血液透析(MHD)合并长期高血压患者采用血液灌流法(HP)治疗的效果。方法选取2016年1月至2018年1月本院收治的MHD合并长期高血压患者86例为研究对象,根据治疗方法进行分组,将采用HP治疗的患者纳入对照组(n=37),将采用HP联合常规血液透析(HD)治疗的患者纳入观察组(n=49),比较两组治疗效果,分析对患者血压水平和氧化激素及神经内分泌激素水平的影响。结果治疗后观察组收缩压及舒张压显著降低,且低于对照组,差异有统计学意义(P<0.05),对照组治疗前后收缩压及舒张压比较差异无统计学意义;治疗后两组血浆超氧化物歧化酶(SOD)水平显著升高,丙二醛(MDA)、肾素(PRA)、血管紧张素Ⅱ(AngⅡ)水平均显著降低,且观察组治疗后SOD水平高于对照组,MDA、PRA、AngⅡ水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后皮肤瘙痒正常比例72.93%明显高于对照组53.06%,差异有统计学意义(P<0.05)。结论 MHD合并长期高血压患者应用HP+HD联合治疗效果较佳,可显著降低患者血压水平及心血管事件发生率,预后好,值得在临床上推广应用。Objective To investigate the effects of hemoperfusion (HP) on patients with long-term hypertension and undergoing maintenance hemodialysis (MHD). Methods 86 patients with long-term hypertension and undergoing MHD who were admitted to the hospital from January 2016 to January 2018 were selected as subjects. According to the treatment methods, patients treated with HP were included in the control group (n=37), while patients treated with HP combined with conventional hematodialysis (HD) were included in the observation group (n=49). The curative effects were compared between the two groups. The effects on blood pressure and levels of oxidation hormones and neuroendocrine hormones were analyzed. Results The systolic blood pressure and diastolic blood pressure of the observation group were significantly decreased after treatment and were lower than those of the control group (P<0.05). There was no significant difference in the systolic blood pressure or diastolic blood pressure of the control group before and after treatment. The levels of superoxide dismutase (SOD) in both groups were significantly increased, while levels of malondialdehyde (MDA), renin (PRA) and angiotensin II (Ang II) were significantly decreased after treatment. The level of SOD in the observation group was higher than that in the control group, while levels of MDA, PRA and AngII were lower than in the control group after treatment (P<0.05). The recovery rate of skin itching in the observation group after treatment was significantly higher than that in the control group (72.93% vs 53.06%)(P<0.05). Conclusion The curative effect of HP combined with HD on patients with long-term hypertension and undergoing MHD is good. The combined treatment can significantly reduce the blood pressure and the incidence of cardiovascular and cerebrovascular events, with good prognosis.

关 键 词：MHD 长期高血压 血液灌流 

分 类 号：R544.1[医药卫生—心血管疾病]