丹参酮Ⅱ_A对脑缺血保护的作用机制研究进展  

Research Progress of the Mechanism of Protective Effect of Tanshinone Ⅱ_A on Cerebral Ischemia

作　　者：王媛媛[1] 陶娌娜[1] 宋燕青[1] 李楠[1] WANG Yuanyuan;TAO Lina;SONG Yanqing;LI Nan(Department of Pharmacy,The First Affiliated Hospital of Jilin University,Changchun,Jilin,China 130021)

机构地区：[1]吉林大学第一医院药学部,吉林长春130021

出　　处：《中国药业》2019年第9期1-4,共4页China Pharmaceuticals

基　　金：2015年度吉林省自然科学基金项目[20150101213JC]

摘　　要：丹参是唇形科多年生草本植物,其脂溶性提取物中丹参酮ⅡA含量最高,且有较高的药用价值,在脑缺血保护中具有抗炎、抗氧化、抑制细胞凋亡等作用。该文综述了丹参酮ⅡA对脑缺血的脑保护作用机制,为丹参酮ⅡA进一步治疗脑缺血研究提供理论参考依据。Salvia miltiorrhiza is a perennial herb of the Labiatae family.The content of tanshinoneⅡA in its fat-soluble extract is the highest,and it has high medicinal value.It has anti-inflammatory,anti-oxidant and anti-apoptosis effects in cerebral ischemia protection.This article reviews the mechanism of the protective effect of tanshinoneⅡA on cerebral ischemia,and provides the theoretical basis and reference materials for further treatment of cerebral ischemia with tanshinoneⅡA.

关 键 词：丹参酮ⅡA 脑缺血 作用机制 进展 

分 类 号：R932[医药卫生—生药学] R285.5[医药卫生—药学]