贵州省两个少数民族地区乙肝感染家庭聚集性影响因素分析  

Risk Factors of Family Aggregation with Hepatitis B Virus Infection in Minority Areas of Guizhou Province Using Multilevel Statistical Model

作　　者：卜苏洪 黄文湧 汪俊华 蒋芝月[1] 官志忠 杨敬源[1,2,4] BU Suhong;HUANG Wenyong;WANG Junhua;JIANG Zhiyue;GUAN hizhong;YANG Jingyuan(School of Public Health, Guizhou Medical University, Guizhou, Guiyang 550025, China;The Key Laboratory of Environmental Pollution and Disease Surveillance, Ministry of Education, Guizhou Medical University, Guizhou,Guiyang 550025, China;Guizhou Institute of Health Development Research, Guizhou, Guiyang 550025, China;The Key Laboratory of Molecular Biology, Guizhou Medical University, Guizhou, Guiyang 550025, China)

机构地区：[1]贵州医科大学公共卫生学院,贵州贵阳550025 [2]贵州医科大学环境污染与疾病监控教育部重点实验室,贵州贵阳550025 [3]贵州医科大学 [4]贵州省卫生发展研究院,贵州贵阳550025 [5]贵州医科大学医学分子生物重点实验室,贵州贵阳550025

出　　处：《贵州医科大学学报》2019年第4期447-452,共6页Journal of Guizhou Medical University

基　　金：科技部"十二五"国家科技支撑计划(2013BAI05B03)

摘　　要：目的:分析贵州省少数民族地区1 629例乙型肝炎病毒(HBV)感染家庭聚集性的影响因素。方法:采用多阶段整群随机抽样的方法,抽取贵州省少数民族地区1 115户家庭1 629人进行调查,同时采集5 mL静脉血检测乙肝5项指标;采用两水平Logistic回归模型分析乙肝感染家庭聚集性的影响因素和保护因素。结果:1 629名居民乙肝感染率为50.6%、HBsAg阳性率为8.3%,1 115户家庭中有132户存在乙肝感染家庭聚集性;两水平Logistic回归分析结果显示,吸烟(OR=1.837,95%CI为1.057～2.917)、一起生活的人HBsAg阳性是贵州省少数民族地区乙肝感染家庭聚集性的危险因素;学生(OR=0.140,95%CI为0.025～0.797)、夫妻同房时使用安全套(OR=0.438,95%CI为0.207～0.927)、接种过乙肝疫苗(OR=0.281,95%CI为0.092～0.863)是保护因素。结论:生活行为方式和接种乙肝疫苗是贵州省少数民族地区乙肝感染家庭聚集性的主要影响因素。Objective: To analyze risk factors of family aggregation with hepatitis B virus(HBV) infection in minority areas of Guizhou Province. Methods: A total of 1629 permanent residents from 1 115 families were enrolled using multistage cluster random sampling in minority areas of Guizhou province in 2013. 5 mL venous blood was collected to detect five HBV serological indexes. Two-level logistic regression model was used to analyze risk factors and protective factors of family aggregation with HBV infection. Results: 50.6% of 1629 permanent residents was infected by HBV, and 8.3%(136/1629)was HBsAg positive. Among the 1115 households with HBV infection, 132 households had family aggregation. Two-level logistic regression analysis showed that smoking(OR=1.837, 95% CI:1.057~2.917) and living with HBsAg positive people are risk factors to infect HBV, leading to family aggregation in minority areas of Guizhou Province;students(OR=0.140, 95% CI: 0.025~0.797), condom use for sex OR=0.438, 95% CI: 0.207~0.927) and vaccination with HB vaccine(OR=0.281, 95% CI: 0.092~0.863) are protective factors. Conclusion: Life behavior and hepatitis B vaccination are the main influencing factors leading to family aggregation of hepatitis B infection in minority areas of Guizhou Province.

关 键 词：肝炎 乙型 家庭特征 少数民族卫生 回归分析 影响因素 

分 类 号：R183.9[医药卫生—流行病学]