静脉输注丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果  

Clinical effect of intravenous infusion gammaglobulin combined with aspirin in the treatment of Kawasaki disease in children

作　　者：黄咏梅 HUANG Yong-mei(Pediatrics Department, the Hospital of Jing County, Xuancheng 242500, China)

机构地区：[1]安徽省泾县医院儿科,安徽宣城242500

出　　处：《临床医学研究与实践》2019年第12期61-62,共2页Clinical Research and Practice

摘　　要：目的探讨静脉输注丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果。方法回顾性分析2012年1月至2018年8月我院收治的26例川崎病患儿的临床资料。所有患儿均给予口服阿司匹林联合大剂量丙种球蛋白静脉滴注治疗,分析其治疗效果。结果治疗后,患儿的WBC、ESR、CRP、PLT水平明显低于治疗前(P<0.05)。本研究中,患儿治疗显效18例,有效8例,总有效率为100.0%(26/26)。治疗后,患儿均未发生心脏冠状动脉扩张等并发症。患儿临床症状缓解时间与住院时间分别为(5.7±1.8)、(10.2±1.2)d。结论阿司匹林联合静脉滴注丙种球蛋白治疗小儿川崎病效果显著,其不仅能改善患儿的血清指标水平,还可减少心脏冠状动脉损伤等并发症,值得临床大力推广。Objective To explore the clinical effect of intravenous infusion gammaglobulin combined with aspirin in the treatment of Kawasaki disease in children. Methods The clinical data of 26 children with Kawasaki disease admitted in our hospital from January 2012 to August 2018 were retrospectively analyzed. All children were treated with oral aspirin combined with a large dose of gammaglobulin intravenous infusion. The therapeutic effect was analysed. Results After treatment, the levels of WBC, ESR, CRP and PLT of children were significantly lower than those before treatment(P<0.05). In this study, 18 cases were markedly effective and 8 cases were effective. The total effective rate of treatment was 100.0%(26/26). After treatment, there were no complications such as coronary artery dilatation in children. The remission time of clinical symptoms and hospitalization time of children were(5.7 ±1.8) and(10.2±1.2) d. Conclusion Aspirin combined with intravenous infusion gammaglobulin has a remarkable effect in children with Kawasaki disease. It can not only improve the levels of serum indexs of children, but also reduce complications such as cardiac and coronary artery injury, which is worthy of further promotion in clinic.

关 键 词：丙种球蛋白 川崎病 阿司匹林 

分 类 号：R725.4[医药卫生—儿科]