大剂量黄芪及银杏达莫治疗糖尿病肾病Ⅲ～Ⅳ期的临床效果  

Clinical effect of large dosage of astragalus membranaceus and ginkgo leaf extract and dipyridamole on stage Ⅲ-Ⅳ diabetic nephropathy

作　　者：尚国涛[1] 任利 SHANG Guo-tao;REN Li(Yangling Demonstration Zone Hospital (Clinical Hospital of Shaanxi Provincial People's Hospital), Xianyang 712100, China)

机构地区：[1]杨凌示范区医院(陕西省人民医院临床医院),陕西咸阳712100

出　　处：《临床医学研究与实践》2019年第12期111-113,共3页Clinical Research and Practice

摘　　要：目的探讨大剂量黄芪及银杏达莫治疗糖尿病肾病Ⅲ～Ⅳ期的临床效果。方法选择本科室2012年1月至2018年6月收治的60例糖尿病肾病Ⅲ～Ⅳ期患者为研究对象,采取随机数表法将其分为常规组(n=30)和干预组(n=30)。常规组采取常规对症治疗+银杏达莫治疗,干预组在常规组基础上采用大剂量黄芪治疗。比较两组的治疗效果、治疗前、后血液流变学指标、氧化应激指标、肾功能指标水平及用药安全性。结果干预组的治疗总有效率高于常规组(P<0.05)。治疗后,两组全血高切粘度、全血低切粘度、丙二醛水平、24 h尿蛋白定量及血肌酐水平均降低,且干预组低于常规组(P<0.05)。治疗后,两组超氧化物歧化酶及血浆白蛋白水平均升高,且干预组高于常规组(P<0.05)。两组用药不良反应总发生率无显著差异(P>0.05)。结论大剂量黄芪及银杏达莫治疗糖尿病肾病Ⅲ～Ⅳ期的临床效果显著,可改善患者血液微循环、蛋白尿及低蛋白血症,并减轻氧化应激及肾损伤。Objective To investigate the clinical effect of large dosage of astragalus membranaceus and ginkgo leaf extract and dipyridamole on stage Ⅲ-Ⅳ diabetic nephropathy. Methods Sixty patients with stage Ⅲ-Ⅳ diabetic nephropathy admitted in our department from January 2012 to June 2018 were selected as study objects and randomly divided into routine group(n=30) and intervention group(n=30). The routine group was treated with routine symptomatic treatment +ginkgo leaf extract and dipyridamole, and the intervention group was treated with large dosage of astragalus membranaceus on the basis of the routine group. The therapeutic effects, hemorheological indexes, oxidative stress indexes,renal function indexes before and after treatment and medication safety were compared between the two groups. Results The total effective rate of treatment in the intervention group was significantly higher than that in the routine group(P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, malondialdehyde level, 24-hour urinary protein quantification and serum creatinine level of the two groups decreased, and those in the intervention group were lower than the routine group(P<0.05). After treatment, the levels of superoxide dismutase and plasma albumin in both groups increased, and those in the intervention group were higher than the routine group(P<0.05). There was no significant difference in the total incidences of adverse drug reactions between the two groups(P>0.05). Conclusion Large dosage of astragalus membranaceus and ginkgo leaf extract and dipyridamole has significant clinical effect in the treatment of stage Ⅲ-Ⅳ diabetic nephropathy, it can improve blood microcirculation, proteinuria and hypoproteinemia, and alleviate oxidative stress and renal injury.

关 键 词：大剂量黄芪 银杏达莫 糖尿病肾病 蛋白尿 低蛋白血症 

分 类 号：R259[医药卫生—中西医结合]