金连菊复方制剂对大鼠的亚慢性毒性试验  

Test for Subchronic Toxicity of Jinlianju Compound Preparation to Rat

作　　者：兰宗宝[1] 俸祥仁 张鑫 何莫斌 陈德元[1] 罗丽[1] 陈燕[1] LAN Zong-bao;FENG Xiang-ren;ZHANG Xin;HE Mo-bin;CHEN De-yuan;LUO Li;CHEN Yan(Agricultural Science and Technology Information Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China;Qiangwei Agriculture and Animal Husbandry Technology Limited Company in Nanning, Guangxi, Nanning 530001, China;Baipeng Stud Stock Farm in Guangxi, Liuzhou 541502, China)

机构地区：[1]广西农业科学院农业科技信息研究所,广西南宁530007 [2]广西南宁强微农牧科技有限公司,广西南宁530001 [3]广西百朋种畜场,广西柳州541502

出　　处：《江西农业学报》2019年第4期82-86,共5页Acta Agriculturae Jiangxi

基　　金：南宁市科学研究与技术开发计划项目(20152309);广西水产畜牧科技推广应用项目(桂渔牧科201528001);广西南宁市西乡塘区科学研究与技术开发计划项目(20810203)

摘　　要：以Wistar大鼠为动物模型开展了不同浓度(0.5、1.0、2.0和5.0 g/mL)金连菊复方制剂的亚慢性毒性试验。结果表明:在整个90 d试验期间,所有供试Wistar大鼠未见死亡和明显的中毒症状,生长活动基本正常;各给药剂量组Wistar大鼠除个别检测指标较对照组(CK,灌服蒸馏水)呈显著(P<0.05)或极显著(P<0.01)升高或降低变化外,整体上其体重增长速率、脏器系数、血常规指标、血清生化指标及主要脏器组织结构与CK相比无明显变化。说明长期服用金连菊复方制剂对Wistar大鼠无亚慢性毒性作用,安全性好。The test for the subchronic toxicity of different concentrations(0.5, 1.0, 2.0 and 5.0 g/mL) of Jinlianju compound preparation to Wistar rats was conducted. The results indicated that: in the whole 90-day test period, all tested Wistar rats did not die or did not exhibit obvious toxic symptoms, and their growth and activities were basically normal;in comparison with the control group(CK, feeding with distilled water), except that several indexes of Wistar rats in various compound preparation treatment groups were significantly(P<0.05) or extremely significantly(P<0.01) increased or decreased, their body weight growth rate, organ coefficient, blood routine indexes, serum biochemical indicators and main organ tissue structure generally had no obvious changes. The above results showed that the long-term application of Jinlianju compound preparation had no subchronic toxicity to Wistar rats, and it was safe.

关 键 词：金连菊复方制剂 WISTAR大鼠 亚慢性毒性 饲料添加剂 

分 类 号：S567.79[农业科学—中草药栽培]