多囊卵巢综合征患者外周血Chemerin水平的变化  

Changes on the level of Chemerin in peripheral blood of patients with polycystic ovary syndrome

作　　者：刘志勤[1] 赖清华 宋艳娥 龙娜[2] 李慧[2] LIU Zhi-Qin;LAI Qing-hua;SONG Yan-e;LONG Na;LI Hui(Department of Gynaecology, Shenzhen Baoan District Maternal and Child Health Hospital, Shenzhen 518106, Guangdong, CHINA;Department of Reproductive Health 2, Shenzhen Baoan District Maternal and Child Health Hospital, Shenzhen 518106, Guangdong, CHINA)

机构地区：[1]深圳市宝安区妇幼保健院妇科,广东深圳518106 [2]深圳市宝安区妇幼保健院生殖健康科,广东深圳518106

出　　处：《海南医学》2019年第7期829-831,共3页Hainan Medical Journal

基　　金：广东省深圳市宝安区科技计划项目(编号:2013079)

摘　　要：目的对比多囊卵巢综合征(PCOS)患者与正常育龄妇女外周血Chemerin水平的差异,并分析其影响因素。方法将2017年1月至2018年3月在深圳市宝安区妇幼保健院妇科、生殖健康科门诊就诊的42例PCOS患者作为PCOS组,同期在上述科室进行孕前体检的正常妇女43例作为对照组,采用酶联免疫吸附法检测两组研究对象外周血Chemerin水平,并采用线性回归分析代谢指标及性激素水平与研究对象Chemerin水平的相关性。结果 PCOS患者外周血Chemerin水平为(134.5±41.0) ng/mL,明显高于对照组的(94.8±52.1) ng/mL,差异有显著统计学意义(P<0.001);PCOS患者外周血Chemerin水平与体质量指数(BMI)及空腹血糖水平呈正相关(r值分别为0.034和0.004,P值均<0.05),但与促卵泡生成素、雌二醇等性激素水平无相关(r值分别为0.009和0.257,P值均>0.05);正常妇女的Chemerin水平与上述指标均无关系(P值均>0.05)。结论 PCOS患者外周血中Chemerin水平明显升高,且与代谢紊乱相关,将来可作为该病及其代谢状态的生物标志物。Objective To compare the Chemerin levels in peripheral blood between patients with polycystic ovary syndrome(PCOS) and controls, and then to analyze the related risk factors. Methods Chemerin levels in peripheral blood of 42 patients with PCOS and 43 normal reproductive women were detected using enzyme-linked immunosorbent assay, and the associations of the Chemerin levels with metabolic indicators and sex hormone levels were further analyzed by linear regression. Results The peripheral blood chemerin level in PCOS patients was significantly higher than that of controls:(134.5±41.0) ng/mL vs(94.8±52.1) ng/mL, P<0.001. The Chemerin level in PCOS patients was correlated with the patient’s body mass index(r=0.034, P<0.05) and fasting blood glucose level(r=0.004, P<0.05), but there was no correlation between the Chemerin level with sexual hormone levels like follicular stimulating hormone(r=0.009,P>0.05) and estradiol(r=0.257, P>0.05). In normal women, Chemerin levels were not correlated with either of the above indicators(all P>0.05). Conclusion Chemerin levels in peripheral blood of PCOS patients are significantly increased and correlated with metabolic disorders. It suggested that Chemerin level might serve as a biomarker for PCOS and its related metabolic status.

关 键 词：多囊卵巢综合征 CHEMERIN 体质量指数 代谢紊乱 性激素 

分 类 号：R711.75[医药卫生—妇产科学]