光动力治疗光源的研究新进展  

Recent Advances in Light Sources for Photodynamic Therapy

作　　者：梁富强 沈毅[1] 顾瑛[2] 布瑞恩.坎贝尔.威尔逊 李步洪[1] LIANG Fuqiang;SHEN Yi;GU Ying;WILSON Campbell Brian;LI Buhong(Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, Fujian, China;Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China;Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto M5G 2M9, Canada)

机构地区：[1]福建师范大学医学光电科学与技术教育部重点实验室福建省光子技术重点实验室,福建福州350007 [2]中国人民解放军总医院激光医学科,北京100853 [3]多伦多大学生物物理与成像研究部玛格丽特癌症研究所

出　　处：《激光生物学报》2019年第2期97-108,共12页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(61635014;61520106015);教育部科技创新团队项目(IRT-15R10)

摘　　要：光动力疗法(PDT)是一种联合利用治疗光源、光敏剂和氧分子,选择性治疗恶性肿瘤和良性疾病的精准靶向疗法。光源作为PDT治疗的关键要素之一,其发光波长、照光方式和剂量直接影响疗效。本文详细介绍了太阳光、近红外光、X射线、在体发光和发光二极管等5种PDT光源的研究新进展,并分析了这五种治疗光源在生物组织穿透深度上的不同特性以及所存在的不足。随后,重点讨论了以提高PDT治疗精度为目标的体表照光和体内照光等两种个性化照光模式。研发操作简便、价格低廉、性能优异的新型PDT光源是未来的发展方向。Photodynamic therapy (PDT)is a promising therapeutic modality that can selectively destroy oncological and non-oncological diseases with photosensitizer activated by specific wavelength light in the presence of oxygen. The efficiency of PDT depends strongly on the selection of irradiation light, including emission wavelength, irradiation mode and treatment dose. In this review, recent advances in the five kinds of PDT light sources, including daylight, near infrared light, X-ray, internal light and light emitting diode were introduced in detail. Meanwhile, the advantages and limitations of each light source are discussed. Furthermore, in order to achieve the personalized irradiation mode for improving the therapeutic effects and preciseness of clinical PDT, the surface and internal light irradiation were described. The developments of new PDT light sources with easier operation, lower price and greater performance are highlighted.

关 键 词：光动力疗法 光源 组织光学 近红外光 X射线 发光二极管 

分 类 号：R454.2[医药卫生—治疗学]