莫匹罗星联合氦氖激光照射治疗新生儿脐炎的临床疗效研究  

A Clinical Effective Study of Mupirocin and He-Ne Laser Radiation Therapy on Neonatal Omphalitis

作　　者：钟严艳[1] 蔡馥丞[2] 王娜 査慧 冯自波 ZHONG Yanyan;CAI Fucheng;WANG Na;ZHA Hui;FENG Zibo(Pediatric Department of Huazhong University of Science and Technology Hospital, Wuhan 430074, Hubei, China;Pediatric Department of Union Hospital Affiliated to Huazhong University of Science and Technology, Wuhan 430022,Hubei, China;Wound Repair Center of Li Yuan Hospital Affiliated to Huazhong University of Science and Technology, Wuhan 430077, Hubei, China)

机构地区：[1]华中科技大学医院儿科,湖北武汉430074 [2]华中科技大学同济医学院附属协和医院儿科,湖北武汉430022 [3]华中科技大学附属梨园医院创面修复中心,湖北武汉430077

出　　处：《激光生物学报》2019年第2期183-187,共5页Acta Laser Biology Sinica

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.14178);国家自然科学基金青年项目(81501297)

摘　　要：为探讨莫匹罗星联合氦氖激光照射治疗新生儿脐炎的临床疗效,本研究选取了2013至2018年新生儿脐炎患儿86例,通过对照研究,按治疗方法不同分为观察组(莫匹罗星+氦氖激光照射)与对照组(莫匹罗星)各43例,观察两组患儿新生儿脐炎愈合时间及不良反应发生情况。试验发现观察组平均愈合时间为(4. 186±0. 194) d,总有效率为100%;对照组平均愈合时间为(5. 189±0. 238) d,总有效率为86%;观察组愈合时间显著高于对照组(P <0. 05)。两组患儿在治疗期间均未发现皮肤红疹等不良事件。研究结果显示,莫匹罗星联合氦氖激光照射治疗新生儿脐炎的临床疗效确切,安全性高。To investigate clinical effectiveness of mupirocin and He-Ne laser radiation on neonatal omphalitis through the controlled study. 86 cases of neonatal omphalitis was selected from 2013 to 2018, divided into observation group (mupirocin + He-Ne laser therapy)and the control group (mupirocin)according to different treatments, with 43 cases in each group. Neonatal omphalitis healing time and adverse event was recorded .It was found that the average healing time of observation group was (4.186±0.194)d, the total effective rate was 100%, and average healing time was (5.189±0.238)d, the total effective rate was 86%on the control group. Healing time of observation group were significantly higher than that of control group ( P <0.05). Adverse events such as skin rash were not found in two groups. Study shows that mupirocin combined with He-Ne laser radiation therapy for the treatment of neonatal omphalitis have good clinical curative effect, high safety.

关 键 词：新生儿脐炎 莫匹罗星 氦氖激光照射 临床疗效 

分 类 号：R72[医药卫生—儿科]