达格列净与2型糖尿病患者泌尿生殖系统感染相关性的Meta分析  

Correlation Between the Dapagliflozin and Urinary Tract Infection or Genital Infection in Patients with Type 2 Diabetes Mellitus: a Meta-Analysis

作　　者：张爱玲[1] 李朵璐[1] 周玉冰[1] 时程程 康建[1] 张晓坚[1] ZHANG Ailing;LI Duolu;ZHOU Yubing;SHI Chengcheng;KANG Jian;ZHANG Xiaojian(Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)

机构地区：[1]郑州大学第一附属医院药学部,郑州450052

出　　处：《医药导报》2019年第5期650-655,共6页Herald of Medicine

基　　金：郑州大学第一附属医院院内青年基金(20150618);常州四药临床药学科研基金(CZSYJJ15002)

摘　　要：目的系统评价2型糖尿病患者服用达格列净后出现泌尿生殖系统感染的风险,为临床提供用药参考。方法计算机检索PubMed、EMbase、The Cochrane Library、Clinical Trials数据库,查找关于达格列净与泌尿生殖系统感染的相关临床研究,检索时限均为从建库至2018年1月8日。对符合条件的研究,由2位研究者按照纳入和排除标准,独立筛选文献、提取资料、评价文献质量,并交叉核对后,采用Stata 12.0版软件进行Meta分析。结果共纳入25篇文献,包括25个研究(n=11 199);结果显示,与安慰药比较,达格列净导致泌尿生殖系统感染的风险较高(P<0.05);服用达格列净的女性患者较男性患者发生泌尿生殖系统感染的风险高(P<0.05)。结论 2型糖尿病患者服用达格列净治疗时,应定期监测尿常规和检查生殖系统,若发生尿路感染或生殖系统感染时尽量换用其他药物治疗,避免感染加重。Objective To evaluate the correlation between the dapagliflozin and urinary tract and genital infection in patients with type 2 diabetes mellitus (T2DM) and provide reference for clinical safe use. Methods Randomized, placebo-controlled, double-blinded clinical trials reported the association between dapagliflozin and urinary tract or genital infection were collected in electronic databases, including PubMed, EMbase, the Cochrane Library and Clinical Trials until January 8th 2018. Two authors assessed, extracted and crosschecked data according to the literature inclusion and exclusion criteria independently. Data were analyzed by Stata 12.0. Results Twenty-five clinical trials ( n =11 199) were included.Comparing to placebo group, the risk of urinary tract infection and genital infection were significant higher ( P <0.05). Besides, the incidence rate was higher in female patients than male patients ( P <0.05). Conclusion The patients with T2DM who received dapagliflozin should regularly monitor urine routine and reproductive system. If urinary tract infection or genital infection occurred, T2DM patients should switch to other medications to avoid severe infections.

关 键 词：达格列净 感染 尿路 感染 生殖系统 META分析 糖尿病 2型 

分 类 号：R977.15[医药卫生—药品] R691.3[医药卫生—药学]