蛋白质结构域划分方法及在线服务综述  

A review of protein domain partitioning methods and online services

作　　者：王燕[1] 石强[2] 薛志东[2] WANG Yan;SHI Qiang;XUE Zhi-dong(School of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China;School of Software Engineering,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]华中科技大学生命学院,湖北武汉430074 [2]华中科技大学软件学院,湖北武汉430074

出　　处：《广州大学学报（自然科学版）》2019年第1期20-29,共10页Journal of Guangzhou University:Natural Science Edition

基　　金：国家自然科学基金资助项目(61772217)

摘　　要：蛋白质结构域是研究蛋白质结构、功能与进化的基本单位,不同的结构域可组合出更为复杂的蛋白质分子.划分蛋白质结构域后,可以从结构域的角度研究蛋白质的结构、功能与进化,降低了研究复杂度.根据已知结构的蛋白质统计,有约40%的为多结构域蛋白质,其中还存在一级结构上不临近的氨基酸序列出现在同一个结构域的情况,即不连续结构域.文章给出了当前国内外有关蛋白质结构域边界预测、不连续结构域检测及结构域数据库与在线服务的研究进展,供相关研究者参考.Protein domains are the basic units for the structure, function and evolution of proteins. Different domains can be used to construct more complex protein molecules. After delineating the protein domain, the structure, function and evolution of the protein can be studied from the perspective of the domain, which reduces the research complexity. According to the protein statistics of known structures, about 40% are multi-domain proteins, in which there are also cases that amino acid sequences that are not structurally adjacent to each other appear in the same domain, i.e., discontinuous domains. This paper presents the current research progress on protein domain boundary prediction, discontinuous domain detection, domain database and online service at home and abroad, for relevant researchers reference.

关 键 词：蛋白质 结构域 不连续结构域 预测 在线服务 

分 类 号：Q518[生物学—生物化学]