紫癜方加减联合西药治疗儿童过敏性紫癜的回顾性研究  

Retrospective study of modified Zidian formula combined with western medicine in the treatment of children with Henoch-Sch?nlein purpura

作　　者：龙军颖 刘晓鹰[2] 朱伊娜 LONG Junying;LIU Xiaoying;ZHU Yina(Hubei University of Traditional Chinese Medicine, Wuhan 430060, China)

机构地区：[1]湖北中医药大学 [2]湖北省中医院儿科,武汉430060 [3]武汉市第一医院儿科,武汉430022

出　　处：《中国中西医结合儿科学》2019年第2期151-154,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目[国中医药人教发(2010)59号]

摘　　要：目的观察紫癜方加减联合西药治疗儿童过敏性紫癜的临床疗效,以期为该病的专病诊疗提供临床参考和优化思路。方法收集2015年1月至2018年6月于湖北省中医院给予紫癜方加减联合西药治疗的过敏性紫癜患儿121例进行回顾性研究,选取2周作为评价节点观察治疗前后患儿症状、体征变化,选取半年作为评价节点观察治疗前后患儿皮疹复发及肾损害变化。结果治疗2周后,皮疹疗效总有效率达97.52%(118/121),难治性皮疹总有效率达86.36%(19/22);治疗2周后中医证候主症总积分、次症总积分、总积分均低于治疗前,差异有统计学意义(P<0.05);中医证候疗效总有效率为97.52%(118/121)。治疗半年86例有皮疹复发,治疗半年内复发次数显著低于治疗前半年,差异有统计学意义(P<0.05)。治疗前无肾损害者82例,随访治疗的半年,9例出现新发肾损害,肾损害发生率为10.98%(9/82)。结论紫癜方加减联合西药治疗儿童过敏性紫癜能有效减轻患儿临床症状,减少皮疹复发,并有减少过敏性紫癜肾损害的可能,且安全性高。Objective To observe the clinical efficacy of modified Zidian formula combined with western medicine in the treatment of children with Henoch-Sch nlein purpura, in order to provide clinical reference and optimization ideas for the diagnosis and treatment of the disease. Methods A retrospective study was performed on 121 children with Henoch-Sch nlein purpura who were treated with modified Zidian formula combined with western medicine in Hubei Provincial Hospital of Traditional Chinese Medicine from January 2015 to June 2018. The patients were followed up for 2 weeks as evaluation point to observe the signs and symptoms before and after treatment. Take half a year as an evaluation point to observe the recurrence of rash and renal damage in children before and after treatment. Results After 2 weeks of treatment, the total effective rate on rash was 97.52%(118/121), and the total effective rate on refractory rash was 86.36%(19/22). After 2 weeks of treatment, the TCM syndrome major total points, minor total points and total points were lower than before treatment, and the difference was statistically significant( P <0.05). The total effective rate on TCM syndromes was 97.52%(118/121). There were 86 cases of recurrent rash after half a year of treatment, and the frequency of recurrence within half a year of treatment was significantly lower than that in the half a year before treatment, with statistically significant difference( P <0.05). There were 82 cases without renal damage before treatment, and 9 cases showed new renal damage in the half-year follow-up, with the incidence of renal damage being 10.98%(9/82). Conclusion Modified Zidian formula combined with western medicine in the treatment of children with Henoch-Sch nlein purpura can effectively alleviate the clinical symptoms, reduce the recurrence of skin rash, and reduce the possibility of allergic purpura renal damage, and it has a high safety.

关 键 词：过敏性紫癜 回顾性研究 临床疗效 专病诊疗 紫癜方 儿童 

分 类 号：R554.6[医药卫生—血液循环系统疾病]