基于二维二氧化锰纳米片的全固态钾离子选择性电极测定血钾浓度  

Determination of Concentration of Serum Potassium Ion Using All-Solid-State Potassium Ion Selective Electrode Based on Two-Dimensional Manganese Dioxide Nanosheet

作　　者：杨成[1] 宋彩侨 张亚旗 曲瑶[1] YANG Cheng;SONG Cai-Qiao;ZHANG Ya-Qi;QU Yao(State Key Laboratory of Fine Chemicals, School of Chemical Engineering,Dalian University of Technology, Dalian 116024, China)

机构地区：[1]大连理工大学精细化工国家重点实验室化工学院,大连116024

出　　处：《分析化学》2019年第5期765-771,共7页Chinese Journal of Analytical Chemistry

基　　金：中央高校基本科研业务费专项资金(Nos.DUT17LAB18;DUT15RC(3)064);辽宁省博士科研启动基金项目(No.201501167);电分析化学国家重点实验室开放课题(No.SKLEAC201604)资助~~

摘　　要：以二维二氧化锰(MnO_2)纳米片为离子-电子转换层(固体接触层),以玻碳电极为基底,以含有缬氨霉素作为离子载体的聚合物膜为离子选择性膜,构建了全固态K^+选择性电极。由于MnO_2纳米片具有快速充放电的特性,以其作为离子-电子转导层可有效提高离子-电子转换效率、降低K^+选择性电极的电阻,在水层测试和抗干扰实验中表现出良好的性能,提高了电极电位响应速度及稳定性。此全固态K^+选择性电极对K^+的线性响应范围为1.0×10^(-5)～1.0×10^(-2) mol/L,检出限为6.3×10^(-6) mol/L。将此全固态K^+选择性电极用于实际血清样品中K^+的测定,结果令人满意,可实现血钾的快速、准确检测。Potassium is an indispensable element of the human body. The disorder of potassium concentration is one of the most common electrolyte disorders in the clinic. The imbalance of potassium concentration makes the myocardial contraction ability abnormal, causing arrhythmia, leading to shock and even death. Therefore, real-time and accurate detection of blood potassium is extremely important for saving lives. In this paper, a 2D MnO 2 nanosheet was used as an ion-electron conversion layer (solid contact layer) to construct an all solid-state Potassium ion selective electrode whose membrane based on a glassy carbon electrode and a polymer membrane containing valinomycin as an ionophore. The results showed that MnO 2 nanosheets had the characteristics of rapid charge and discharge, and their use as ion-electron transducing layers could effectively improve the ion-electron conversion efficiency and reduce the resistance of potassium ion selective electrodes in water layer testing and anti-interference experiments. It exhibited good performance and improved electrode potential response speed and stability. The linear response range of the all-solid potassium ion selective electrode was 1.0×10^-5 -1.0×10^-2 mol/L, and the detection limit was 6.3×10^-6 mol/L. Rapid and accurate detection of serum potassium was achieved using this all-solid-states potassium ion selective electrode.

关 键 词：二氧化锰纳米片 钾离子选择性电极 全固态选择性电极 血钾浓度 

分 类 号：R446.1[医药卫生—诊断学] O657.1[医药卫生—临床医学]