口服复方甘草酸苷联合常规疗法治疗皮炎湿疹疗效及安全性的Meta分析  

Meta-analysis of the Efficacy and Safety of Compound Glycyrrhizin Plus Different Conventional Therapy for Eczema

作　　者：周俐宏 孙晓丽 柳舟 李邻峰[1] Zhou Lihong;Sun Xiaoli;Liu Zhou;Li Linfeng(Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《中国中西医结合皮肤性病学杂志》2019年第2期97-102,共6页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的对口服复方甘草酸苷联合常规疗法治疗皮炎湿疹的疗效及安全性进行系统性分析。方法计算机检索Pubmed、Embase、Medline、Cochrane Library等英文数据库及CBM、CNKI、万方数字化期刊全文数据库及VIP中国科技期刊全文数据库等中文数据库,收集整理所有研究观察口服复方甘草酸苷治疗皮炎湿疹类皮肤病临床疗效的随机对照试验,检索的时间范围为各数据库建库至2018年5月。对检出文献进行筛选、采用RevMan5.3进行Meta分析。结果最终纳入14篇研究,所有临床研究均报道了口服复方甘草酸苷治疗皮炎湿疹疗效的计数资料,以总有效率=(痊愈率+显效率)作为疗效指标进行Meta分析,合并统计量OR值及95%CI为(OR=2.92,95%CI:2.22～3.86),(P<0.000 01)。不良反应发生率合并统计量OR值及95%CI为(OR=1.18,95%CI:0.61～2.27),(P=0.62)。根据联用药物的不同进行亚组分析,分为复方甘草酸苷单独联用外用药组及复方甘草酸苷同时联用外用药及抗组胺药组,总有效率亚组分析统计合并量分别为(OR=3.07,95%CI:1.93～4.88),(P<0.000 01);(OR=2.83,95%CI:1.90～4.19),(P<0.000 01);不良反应发生率亚组分析统计合并量分别为(OR=0.50,95%CI:0.12～2.08),(P=0.34);(OR=1.77,95%CI:0.78～4.01),(P=0.17)。结论本研究结果表明,口服复方甘草酸苷联合常规疗法治疗皮炎湿疹类皮肤病的疗效优于常规疗法,且未增加不良反应发生率。同时,复方甘草酸苷单独联用外用药与同时联用外用药及抗组胺药的疗效相当,且均未增加不良事件的发生。但此次研究因纳入的文献质量及数量的关系,有一定局限性,因此还需扩大样本量进行更深入的研究,以得出更为准确的结论。Objective In order to evaluate the efficacy and safety of compound glycyrrhizin in combination with conventional therapy for eczema. Methods PubMed,Embase,Medline,Cochrane library,CBM,CNKI,CQVIP and Wanfang Data were searched from their respective inceptions to May 2018. Randomized controlled trials comparing compound glycyrrhizin plus conventional therapy to conventional therapy alone for eczema were included. Data analysis was performed using Review Manager 5.3. Results Fourteen randomized controlled trials were included. Compared with conventional therapy,addition of compound glycyrrhizin increased effective rate(OR=2.92,95%CI:2.22~3.86),(P<0.000 01),with not increasing the adverse events(OR =1.18,95% CI:0.61 ~2.27),(P =0.62). Compound glycyrrhizin plus topical corticosteroids alone,and the compound glycyrrhizin in conjunction with topical corticosteroids as well as antihistamine showed similar effects(OR =3.07,95%CI:1.93~4.88),(P<0.000 01) and(OR=2.83,95%CI:1.90~4.19),(P<0.000 01) respectively,and they all did not increase the adverse events(OR =0.50,95% CI:0.12 ~2.08),(P =0.34) and(OR =1.77,95% CI:0.78 ~4.01),(P =0.17).Conclusion Compound glycyrrhizin in conjunction with conventional therapy enhances clinical response,and does not increase any additional risk. Compound glycyrrhizin in conjunction with topical corticosteroids is as good as compound glycyrrhizin plus topical corticosteroids as well as antihistamine.

关 键 词：复方甘草酸苷 外用糖皮质激素 抗组胺药 皮炎 湿疹 疗效 META分析 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]