脂蛋白相关磷脂酶A2及其与糖尿病视网膜病变相关性的进展  

Progress in lipoprotein-associated phospholipase A2 and its correlation with diabetic retinopathy

作　　者：李婷婷 谢晓竞[1] LI Tingting;XIE Xiaojing(Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China)

机构地区：[1]南京医科大学附属南京医院南京市第一医院内分泌科,南京210006

出　　处：《临床与病理杂志》2019年第4期863-868,共6页Journal of Clinical and Pathological Research

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是导致不可逆性眼盲的重要原因之一,DR发病与动脉粥样硬化密切相关,其治疗干预靶点成为当今研究的热点。脂蛋白相关磷脂酶A2(lipoproteinassociated phospholipase A2,Lp-PLA2)是一种新型炎症因子,与动脉粥样硬化及炎症反应等相关。了解Lp-PLA2与DR相关性研究现状可能为进一步研究DR治疗提供新的思路。Diabetic retinopathy (DR) is one of the important causes of irreversible blindness. DR is closely related to atherosclerosis, and its therapeutic intervention target has become a hot topic in current research. Lipoproteinassociated phospholipase A2 (Lp-PLA2), as a new inflammation factor, is related to atherosclerosis and inflammatory response. Understanding the current correlation of Lp-PLA2 and DR may provide a novel option in future treatment of DR.

关 键 词：糖尿病视网膜病变 脂蛋白相关磷脂酶A2 动脉粥样硬化 血脂 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]